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Literature summary for 3.4.22.52 extracted from
- Calpain modulates capacitation and acrosome reaction through cleavage of the spectrin cytoskeleton (2010), Reproduction, 140, 673-684.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| calpeptin | complete inhibition at 0.5 mM | Cavia porcellus |  |
| N-acetyl-Leu-Leu-Nle-CHO | complete inhibition at 0.5 mM | Cavia porcellus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | calpain-1 is relocated and translocated from cytoplasm to plasma membrane during capacitation | Cavia porcellus | 5737 | - |
| plasma membrane | calpain-1 is relocated and translocated from cytoplasm to plasma membrane during capacitation | Cavia porcellus | 5886 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | dependent on | Cavia porcellus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 80000 | - |
x * 80000, SDS-PAGE | Cavia porcellus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| filamin-1 + H2O | Cavia porcellus | - |
? | - |
? | |
| spectrin + H2O | Cavia porcellus | - |
? | - |
? | |
| utrophin + H2O | Cavia porcellus | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cavia porcellus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| sperm | - |
Cavia porcellus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| filamin-1 + H2O | - |
Cavia porcellus | ? | - |
? | |
| spectrin + H2O | - |
Cavia porcellus | ? | - |
? | |
| utrophin + H2O | - |
Cavia porcellus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 80000, SDS-PAGE | Cavia porcellus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | calpain-1 inhibits the acrosome reaction and alters the plasma membrane-associated cytoskeleton in spermatozoa | Cavia porcellus |
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Release 2023.1 (January 2023)
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