Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.52 extracted from

  • Esteves, A.R.; Arduino, D.M.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M.
    Dysfunctional mitochondria uphold calpain activation: contribution to Parkinsons disease pathology (2010), Neurobiol. Dis., 37, 723-730.
    View publication on PubMed

Application

Application Comment Organism
medicine calpain and calpain inhibition is a therapeutic tool in Parkinson’s disease Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
MDL-28710 complete inhibition at 100 nM Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent on, dysfunctional mitochondria increase cytosolic calcium, thereby inducing calpain activation Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
NT2-Rho0 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-LLY-7-amido-4-fluoromethylcoumarin + H2O
-
Homo sapiens acetyl-LLY + 7-amino-4-fluoromethylcoumarin
-
?
alpha-synuclein + H2O
-
Homo sapiens 145000 DA fragment + 150 Da fragment + ?
-
?

Synonyms

Synonyms Comment Organism
calpain 1
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens compared to control cybrids, Parkonsin’s disease cybrids reveal a significant increase in calpain activity up

General Information

General Information Comment Organism
malfunction calpain-1 overactivation in mitochondrial-deficient cells promotes caspase-3 activation, calpain inhibition decreases alpha-synuclein oligomerization Homo sapiens