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Literature summary for 3.4.22.52 extracted from

  • Roumes, H.; Leloup, L.; Dargelos, E.; Brustis, J.J.; Daury, L.; Cottin, P.
    Calpains: markers of tumor aggressiveness? (2010), Exp. Cell Res., 316, 1587-1599.
    View publication on PubMed
Search for more literature for 3.4.22.52

Application

Application Comment Organism
medicine mu-calpain is a marker of tumor aggressiveness and is apotential target for limiting development of rhabdomyosarcoma tumor as well as their metastatic behavior Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
calpeptin Z-Leu-Nle-CHO Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ calcium-dependent cysteine protease Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
LHCN-M2 cell
-
 Homo sapiens
-
rhabdomyosarcoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
tert-butyloxycarbonyl-L-leucyl-L-methionine-7-amido-4-chloromethylcoumarin + H2O
-
 Homo sapiens tert-butyloxycarbonyl-L-leucyl-L-methionine + 7-amino-4-chloromethylcoumarin
-
 ?

Synonyms

Synonyms Comment Organism
CAPN1
-
 Homo sapiens
mu-calpain
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function mu-calpain up-regulates alpha- and beta-actin in alveolar rhabdomyosarcoma cells Homo sapiens