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Literature summary for 3.4.22.52 extracted from

  • Kar, P.; Samanta, K.; Shaikh, S.; Chowdhury, A.; Chakraborti, T.; Chakraborti, S.
    Mitochondrial calpain system: an overview (2010), Arch. Biochem. Biophys., 495, 1-7.
    View publication on PubMed
Search for more literature for 3.4.22.52

Inhibitors

Inhibitors Comment Organism Structure
calpastatin mitochondrial mu-calpain is tightly regulated by its endogenous inhibitor calpastatin Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol neuronal cytosol Rattus norvegicus 5829
-
mitochondrion mu-calpain, including both the large and small subunits is present in the mitochondrial intermembrane space Rattus norvegicus 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ the enzyme is Ca2+-dependent Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
mature apoptosis-inducing factor (62 kDa) + H2O Rattus norvegicus cleaved by the mitochondrial mu-calpain near its N-terminus cleaved apoptosis-inducing factor (57 kDa) + ?
-
 ?
mitochondrial major Ca2+ extruding pathway Na+/Ca2+ exchanger + H2O Rattus norvegicus cleaved by the mitochondrial mu-calpain ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-
neuron
-
 Rattus norvegicus
-
smooth muscle
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
mature apoptosis-inducing factor (62 kDa) + H2O cleaved by the mitochondrial mu-calpain near its N-terminus Rattus norvegicus cleaved apoptosis-inducing factor (57 kDa) + ?
-
 ?
mitochondrial major Ca2+ extruding pathway Na+/Ca2+ exchanger + H2O cleaved by the mitochondrial mu-calpain Rattus norvegicus ?
-
 ?
additional information mitochondrial mu-calpain associates with ERp57, whereas, cytosolic mu-calpain does not associate with ERp57 Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
calpain 1
-
 Rattus norvegicus
mu-calpain
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus mu-calpain is activated in neurons after ischemia up

General Information

General Information Comment Organism
physiological function mitochondrial mu-calpain is an initiator of the apoptosis-inducing factor-induced cell death signaling pathway. Mitochondrial calpain plays important roles both in caspase-dependent and -independent pathways in cell death phenomena. Mu-calpain can act as a direct activator of apoptosis-inducing factor release in neuronal cultures challenged with oxygen-glucose deprivation Rattus norvegicus