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BRENDA support

Literature summary for 3.4.22.52 extracted from

  • Govindarajan, B.; Laird, J.; Salomon, R.G.; Bhattacharya, S.K.
    Isolevuglandin-modified proteins, including elevated levels of inactive calpain-1, accumulate in glaucomatous trabecular meshwork (2008), Biochemistry, 47, 817-825.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
reticulum trabeculare elevated levels of calpain-1 in glaucomatous trabecular meshwork. However, calpain activity in glaucomatous trabecular meshwork is only about 50% of that in controls. Modification by iso-levuglandins renders calpain-1 inactive Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-Leu-Leu-Tyr-7-amido-4-trifluoromethyl coumarin + H2O
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Homo sapiens ?
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?