Literature summary for 3.4.22.39 extracted from

Blainey, P.C.; Graziano, V.; Perez-Berna, A.J.; McGrath, W.J.; Flint, S.J.; San Martin, C.; Xie, X.S.; Mangel, W.F.
Regulation of a viral proteinase by a peptide and DNA in one-dimensional space: IV. Viral proteinase slides along DNA to locate and process its substrates (2013), J. Biol. Chem., 288, 2092-2102.

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Activating Compound

Activating Compound	Comment	Organism	Structure
DNA	the enzyme is partially activated by being bound to viral DNA	Human adenovirus sp.
pVIc	the enzyme can be activated by pVIc (GVQSLKRRRCF) to form the enzyme-pVIc complex in the core of the immature virion	Human adenovirus sp.

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli	Human adenovirus sp.

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
23100	-	x * 23100, calculated from amino acid sequence	Human adenovirus sp.

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
core polypeptide pVI + H2O	Human adenovirus sp.	the enzyme cleaves DNA-bound pVI twice, once at its N terminus and then at its C terminus. Cleavage at the C terminus liberates pVIc, the 11-amino acid peptide cofactor	pVIc + ?	-	?

Organism

Organism	UniProt	Comment	Textmining
Human adenovirus sp.	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Human adenovirus sp.

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
core polypeptide pVI + H2O	the enzyme cleaves DNA-bound pVI twice, once at its N terminus and then at its C terminus. Cleavage at the C terminus liberates pVIc, the 11-amino acid peptide cofactor	Human adenovirus sp.	pVIc + ?	-	?

Subunits

Subunits	Comment	Organism
?	x * 23100, calculated from amino acid sequence	Human adenovirus sp.

Synonyms

Synonyms	Comment	Organism
adenovirus proteinase	-	Human adenovirus sp.
AVP	-	Human adenovirus sp.

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Release 2023.1 (January 2023)