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Literature summary for 3.4.22.39 extracted from

  • Graziano, V.; Luo, G.; Blainey, P.C.; Perez-Berna, A.J.; McGrath, W.J.; Flint, S.J.; San Martin, C.; Xie, X.S.; Mangel, W.F.
    Regulation of a viral proteinase by a peptide and DNA in one-dimensional space: II. adenovirus proteinase is activated in an unusual one-dimensional biochemical reaction (2013), J. Biol. Chem., 288, 2068-2080.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
DNA the enzyme is partially activated by being bound to viral DNA Human adenovirus sp.
peptide VIc an 11-amino acid peptide (GVQSLKRRRCF) originating from the C terminus of the precursor protein pVI Human adenovirus sp.

Protein Variants

Protein Variants Comment Organism
C122A inactive Human adenovirus sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
core polypeptide pVI + H2O Human adenovirus sp.
-
?
-
?

Organism

Organism UniProt Comment Textmining
Human adenovirus sp.
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(Leu-Arg-Gly-Gly-NH)2-rhodamine + H2O
-
Human adenovirus sp. ?
-
?
core polypeptide pVI + H2O
-
Human adenovirus sp. ?
-
?

Synonyms

Synonyms Comment Organism
AVP
-
Human adenovirus sp.