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Literature summary for 3.4.22.39 extracted from

  • Graziano, V.; McGrath, W.J.; Suomalainen, M.; Greber, U.F.; Freimuth, P.; Blainey, P.C.; Luo, G.; Xie, X.S.; Mangel, W.F.
    Regulation of a viral proteinase by a peptide and DNA in one-dimensional space: I. binding to DNA and to hexon of the precursor to protein VI, pVI, of human adenovirus (2013), J. Biol. Chem., 288, 2059-2067.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
DNA DNA binding of pVI is the first step in the activation of adenovirus proteinase. The relative kcat/Km is enhanced 110fold in the presence of DNA. When pVIc and DNA are bound to the enzyme, the kcat/Km increases synergistically by 16000fold Human adenovirus sp.
pVIc the C terminus of pVI (GVQSLKRRRCF) activates the adenovirus proteinase. The relative kcat/Km is enhanced 1130fold in the presence of pVIc. When pVIc and DNA are bound to the enzyme, the kcat/Km increases synergistically by 16000fold Human adenovirus sp.

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
23000
-
x * 23000, SDS-PAGE Human adenovirus sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
core polypeptide pVI + H2O Human adenovirus sp.
-
?
-
?

Organism

Organism UniProt Comment Textmining
Human adenovirus sp.
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
core polypeptide pVI + H2O
-
Human adenovirus sp. ?
-
?

Subunits

Subunits Comment Organism
? x * 23000, SDS-PAGE Human adenovirus sp.

Synonyms

Synonyms Comment Organism
adenovirus proteinase
-
Human adenovirus sp.
AVP
-
Human adenovirus sp.