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Literature summary for 3.4.22.32 extracted from
- Bromelain's activity and potential as an anti-cancer agent: Current evidence and perspectives (2010), Cancer Lett., 290, 148-156.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | bromelain has anti-cancer activity, as well as antithrombotic, fibrinolytic, antiedematous, and burn debridement properties | Ananas comosus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Ananas comosus | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Bromelain | - |
Ananas comosus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | bromelain increases expression of p53 as well as Bax in mouse skin papillomas, at the same time, bromelain decreases the activity of cell survival regulators such as Akt and Erk thus promoting apoptotic cell death in tumors. Bromelain reduces CD44 on the surface of mouse and human tumor cells accompanied by diminished cancer cell invasion and substrate attachment as well as by attenuation of de novo protein synthesis. Bromelain can stimulate the innate immune system by activating neutrophils to produce reactive oxygen species | Ananas comosus |
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Release 2023.1 (January 2023)
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