Literature summary for 3.4.22.28 extracted from

Kobayashi, M.; Arias, C.; Garabedian, A.; Palmenberg, A.C.; Mohr, I.
Site-specific cleavage of the host poly(A) binding protein by the encephalomyocarditis virus 3C proteinase stimulates viral replication (2012), J. Virol., 86, 10686-10694.

Search for more literature for 3.4.22.28

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli BL21(DE3)pLysS cells	Encephalomyocarditis virus

Protein Variants

Protein Variants	Comment	Organism
H46A/C159A	catalytically inactive mutant	Encephalomyocarditis virus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
poly(A) binding protein + H2O	Encephalomyocarditis virus	the enzyme cleaves poly(A) binding protein within the C-terminal domain at Q437/G438	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Encephalomyocarditis virus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
poly(A) binding protein + H2O	the enzyme cleaves poly(A) binding protein within the C-terminal domain at Q437/G438	Encephalomyocarditis virus	?	-	?

Synonyms

Synonyms	Comment	Organism
3C proteinase	-	Encephalomyocarditis virus

General Information

General Information	Comment	Organism
physiological function	host poly(A) binding protein cleavage by 3C proteainase regulates encephalomyocarditis virus replication	Encephalomyocarditis virus

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Release 2023.1 (January 2023)