Literature summary for 3.4.22.28 extracted from

Amineva, S.P.; Aminev, A.G.; Palmenberg, A.C.; Gern, J.E.
Rhinovirus 3C protease precursors 3CD and 3CD' localize to the nuclei of infected cells (2004), J. Gen. Virol., 85, 2969-2979.

Search for more literature for 3.4.22.28

Cloned(Commentary)

Cloned (Comment)	Organism
cloned into cDNA and expressed in Escherichia coli BL21 (DE3) pLysS, transfection of HeLa cells	Human rhinovirus sp.
expressed in HeLa cells	Human rhinovirus sp.

Protein Variants

Protein Variants	Comment	Organism
additional information	3CD delta371 with deletion of 371 aa at the carboxyl terminus of 3D	Human rhinovirus sp.

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	mature 3Cpro and precursor 3CD detected 2-4 hours post-infection of HeLa cells	Human rhinovirus sp.	5737	-
additional information	in the perinuclear membrane	Human rhinovirus sp.	-	-
nucleus	mature 3Cpro and precursor 3CD detected 2-4 hours post-infection of HeLa cells	Human rhinovirus sp.	5634	-

Organism

Organism	UniProt	Comment	Textmining
Human rhinovirus sp.	-	HRV-16	-

Purification (Commentary)

Purification (Comment)	Organism
recombinant protein purified to 90% homogeneity	Human rhinovirus sp.

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
human rhinovirus polyprotein + H2O	-	Human rhinovirus sp.	1AB/1C/1D/2C/delta3CD	-	?
transcription factor OCT-1 + H2O	cleaved by 3Cpro, precursor 3CD and mutant 3CD delta371	Human rhinovirus sp.	?	-	?

Synonyms

Synonyms	Comment	Organism
3C protease	-	Human rhinovirus sp.
3Cpro	-	Human rhinovirus sp.

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Release 2023.1 (January 2023)