Literature summary for 3.4.22.28 extracted from

Strong, R.; Belsham, G.J.
Sequential modification of translation initiation factor eIF4GI by two different foot-and-mouth disease virus proteases within infected baby hamster kidney cells: identification of the 3Cpro cleavage site (2004), J. Gen. Virol., 85, 2953-2962.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in baby hamster kidney cells and human A293 cells	Foot-and-mouth disease virus

Protein Variants

Protein Variants	Comment	Organism
P713T	the human eIF4GI mutant is cleaved efficiently by 3Cpro	Foot-and-mouth disease virus

Organism

Organism	UniProt	Comment	Textmining
Foot-and-mouth disease virus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
eIF4GI + H2O	cleavage in baby hamster kidney cells and 3T3 cells, cleavage can occur either on the full-length protein or on the primary cleavage product that is generated by Lpro, human and green monkey eIF4GI is resistant to the action of 3Cpro, a single amino acid substitution renders human eIF4GI sensitive to 3Cpro	Foot-and-mouth disease virus	?	-	?

Synonyms

Synonyms	Comment	Organism
3C protease	-	Foot-and-mouth disease virus
3Cpro	-	Foot-and-mouth disease virus

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Release 2023.1 (January 2023)