Literature summary for 3.4.22.28 extracted from

Matthews, D.A.; Dragovich, P.S.; Webber, S.E.; Fuhrman, S.A.; Patick, A.K.; Zalman, L.S.; Hendrickson, T.F.; Love, R.A.; Prins, T.J.; Marakovits, J.T.; Zhou, R.; Tikhe, J.; Ford, C.E.; Meador, J.W.; Ferre, R.A.; Brown, E.L.; Binford, S.L.; Brothers, M.A.; DeLisle, D.M.; Worland, S.T.
Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes (1999), Proc. Natl. Acad. Sci. USA, 96, 11000-11007.

Crystallization (Commentary)

Crystallization (Comment)	Organism
crystal structure of AG7088 bound to serotype 2 rhinovirus 3C protease, hanging-drop vapor diffusion method	enterovirus

Inhibitors	Comment	Organism	Structure
AG7088	inhibitor with potent antiviral activity against multiple human rhinovirus serotypes, highly specific for picornavirus 3C proteases having negligible inhibitory activity against a panel of mammalian cysteine proteases, including cathepsin B, elastase, chymotrypsin, trypsin and calpain	enterovirus

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
picornavirus polyprotein + H2O	enterovirus	most maturation cleavages within the precursor polyprotein are mediated by the enzyme	hydrolyzed picornavirus polyprotein	-	?

Organism	UniProt	Comment	Textmining
enterovirus	-	human rhinovirus	-

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
picornavirus polyprotein + H2O	most maturation cleavages within the precursor polyprotein are mediated by the enzyme	enterovirus	hydrolyzed picornavirus polyprotein	-	?

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Release 2023.1 (January 2023)