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Literature summary for 3.4.22.28 extracted from

  • Hill, R.D.; Vederas, J.C.
    Azodicarboxamides: a new class of cysteien proteinase inhibitor for hepatitis A virus and human thinovirus 3C enzymes (1999), J. Org. Chem., 64, 9538-9546.
No PubMed abstract available
Search for more literature for 3.4.22.28

Inhibitors

Inhibitors Comment Organism Structure
(E)-2-({2-acetyl-1-[3-(dimethylamino)-3-oxopropyl]hydrazinyl}carbonyl)-N-(2-phenylethyl)diazenecarboxamide potent, irreversible inhibitors with IC50 values in the low micromolar range, probably act by adding the active site thiol to the azo moiety in a Michael fashion to give a covalent complex enterovirus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hepatitis A virus polyprotein + H2O Hepatovirus A the enzyme is essential for viral maturation and infectivity through the cleavage of polyprotein precursor ?
-
 ?
picornavirus polyprotein + H2O Hepatovirus A
-
 hydrolyzed picornavirus polyprotein
-
 ?
picornavirus polyprotein + H2O enterovirus the enzyme is essential for viral maturation and infectivity through the cleavage of polyprotein precursor hydrolyzed picornavirus polyprotein
-
 ?

Organism

Organism UniProt Comment Textmining
enterovirus
-
 human rhinovirus
-
Hepatovirus A
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hepatitis A virus polyprotein + H2O the enzyme is essential for viral maturation and infectivity through the cleavage of polyprotein precursor Hepatovirus A ?
-
 ?
picornavirus polyprotein + H2O
-
 Hepatovirus A hydrolyzed picornavirus polyprotein
-
 ?
picornavirus polyprotein + H2O the enzyme is essential for viral maturation and infectivity through the cleavage of polyprotein precursor enterovirus hydrolyzed picornavirus polyprotein
-
 ?