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Literature summary for 3.4.22.28 extracted from

  • Skern, T.; Liebig, H.D.
    Picornains 2A and 3C (1994), Methods Enzymol., 244, 583-595.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli or BL21(D3) Enterovirus C
expressed in HeLa cells Foot-and-mouth disease virus
expressed in HeLa cells Enterovirus C
expressed in HeLa cells Encephalomyocarditis virus
expressed in HeLa cells enterovirus
expressed in HeLa cells Hepatovirus A
expressed in HeLa cells coxsackievirus
expressed in HeLa cells echovirus
expressed in HeLa cells Mengo virus
expressed in HeLa cells Theiler's encephalomyelitis virus
expressed in HeLa cells picornaviridae

Inhibitors

Inhibitors Comment Organism Structure
chymostatin
-
enterovirus
Elastinal
-
enterovirus
Hg2+
-
coxsackievirus
Hg2+
-
echovirus
Hg2+
-
Encephalomyocarditis virus
Hg2+
-
enterovirus
Hg2+
-
Enterovirus C
Hg2+
-
Foot-and-mouth disease virus
Hg2+
-
Hepatovirus A
Hg2+
-
Mengo virus
Hg2+
-
picornaviridae
Hg2+
-
Theiler's encephalomyelitis virus
iodoacetamide
-
coxsackievirus
iodoacetamide
-
echovirus
iodoacetamide
-
Encephalomyocarditis virus
iodoacetamide
-
enterovirus
iodoacetamide
-
Enterovirus C
iodoacetamide
-
Foot-and-mouth disease virus
iodoacetamide
-
Hepatovirus A
iodoacetamide
-
Mengo virus
iodoacetamide
-
picornaviridae
iodoacetamide
-
Theiler's encephalomyelitis virus
additional information no inhibition by Triton X-100, that inhibits picornain 3CD enterovirus
additional information
-
Enterovirus C
NEM
-
coxsackievirus
NEM
-
echovirus
NEM
-
Encephalomyocarditis virus
NEM
-
enterovirus
NEM
-
Enterovirus C
NEM
-
Foot-and-mouth disease virus
NEM
-
Hepatovirus A
NEM
-
Mengo virus
NEM
-
picornaviridae
NEM
-
Theiler's encephalomyelitis virus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.25 2.6 peptides derived from polyprotein cleavage sites
-
enterovirus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane recombinant enzyme Foot-and-mouth disease virus 16020
-
membrane recombinant enzyme Enterovirus C 16020
-
membrane recombinant enzyme Encephalomyocarditis virus 16020
-
membrane recombinant enzyme enterovirus 16020
-
membrane recombinant enzyme Hepatovirus A 16020
-
membrane recombinant enzyme coxsackievirus 16020
-
membrane recombinant enzyme echovirus 16020
-
membrane recombinant enzyme Mengo virus 16020
-
membrane recombinant enzyme Theiler's encephalomyelitis virus 16020
-
membrane recombinant enzyme picornaviridae 16020
-
membrane rhinovirus, expressed in Escherichia coli enterovirus 16020
-
soluble recombinant enzyme Foot-and-mouth disease virus
-
-
soluble recombinant enzyme Enterovirus C
-
-
soluble recombinant enzyme Encephalomyocarditis virus
-
-
soluble recombinant enzyme enterovirus
-
-
soluble recombinant enzyme Hepatovirus A
-
-
soluble recombinant enzyme coxsackievirus
-
-
soluble recombinant enzyme echovirus
-
-
soluble recombinant enzyme Mengo virus
-
-
soluble recombinant enzyme Theiler's encephalomyelitis virus
-
-
soluble recombinant enzyme picornaviridae
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
activated transcription factor TFIIIC + H2O Enterovirus C in HeLa-cells, poliovirus enzyme, involved in shut-off of host-cell transcription ?
-
?
picornavirus polyprotein + H2O Foot-and-mouth disease virus involved in proteolytic processing of virus polyprotein hydrolyzed picornavirus polyprotein
-
?
picornavirus polyprotein + H2O Enterovirus C involved in proteolytic processing of virus polyprotein hydrolyzed picornavirus polyprotein
-
?
picornavirus polyprotein + H2O Encephalomyocarditis virus involved in proteolytic processing of virus polyprotein hydrolyzed picornavirus polyprotein
-
?
picornavirus polyprotein + H2O enterovirus involved in proteolytic processing of virus polyprotein hydrolyzed picornavirus polyprotein
-
?
picornavirus polyprotein + H2O Hepatovirus A involved in proteolytic processing of virus polyprotein hydrolyzed picornavirus polyprotein
-
?
picornavirus polyprotein + H2O coxsackievirus involved in proteolytic processing of virus polyprotein hydrolyzed picornavirus polyprotein
-
?
picornavirus polyprotein + H2O echovirus involved in proteolytic processing of virus polyprotein hydrolyzed picornavirus polyprotein
-
?
picornavirus polyprotein + H2O Mengo virus involved in proteolytic processing of virus polyprotein hydrolyzed picornavirus polyprotein
-
?
picornavirus polyprotein + H2O Theiler's encephalomyelitis virus involved in proteolytic processing of virus polyprotein hydrolyzed picornavirus polyprotein
-
?
picornavirus polyprotein + H2O picornaviridae involved in proteolytic processing of virus polyprotein hydrolyzed picornavirus polyprotein
-
?

Organism

Organism UniProt Comment Textmining
coxsackievirus
-
-
-
echovirus
-
-
-
Encephalomyocarditis virus
-
-
-
enterovirus
-
human rhinovirus
-
Enterovirus C
-
-
-
Foot-and-mouth disease virus
-
-
-
Hepatovirus A
-
-
-
Mengo virus
-
-
-
picornaviridae
-
overview
-
Theiler's encephalomyelitis virus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
as expressed in Escherichia coli enterovirus
from Escherichia coli membrane fraction enterovirus
recombinant enzyme Enterovirus C
recombinant enzyme from Escherichia coli in soluble form Enterovirus C
recombinant enzyme from infected HeLa cells, to near homogeneity Enterovirus C

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
activated transcription factor TFIIIC + H2O in HeLa-cells, poliovirus enzyme Enterovirus C ?
-
?
activated transcription factor TFIIIC + H2O in HeLa-cells, poliovirus enzyme, involved in shut-off of host-cell transcription Enterovirus C ?
-
?
cardiovirus polyprotein + H2O
-
Foot-and-mouth disease virus ?
-
?
cardiovirus polyprotein + H2O
-
Enterovirus C ?
-
?
cardiovirus polyprotein + H2O
-
Encephalomyocarditis virus ?
-
?
cardiovirus polyprotein + H2O
-
Hepatovirus A ?
-
?
cardiovirus polyprotein + H2O
-
coxsackievirus ?
-
?
cardiovirus polyprotein + H2O
-
echovirus ?
-
?
cardiovirus polyprotein + H2O
-
Mengo virus ?
-
?
cardiovirus polyprotein + H2O
-
Theiler's encephalomyelitis virus ?
-
?
cardiovirus polyprotein + H2O
-
picornaviridae ?
-
?
cardiovirus polyprotein + H2O cleavage specificity enterovirus ?
-
?
encephalomyocarditis virus polyprotein + H2O cleavage sites: Gln-Gly, Glu-Ser and Glu-Ala Encephalomyocarditis virus ?
-
?
enterovirus polyprotein + H2O
-
Foot-and-mouth disease virus ?
-
?
enterovirus polyprotein + H2O
-
Enterovirus C ?
-
?
enterovirus polyprotein + H2O
-
Encephalomyocarditis virus ?
-
?
enterovirus polyprotein + H2O
-
Hepatovirus A ?
-
?
enterovirus polyprotein + H2O
-
coxsackievirus ?
-
?
enterovirus polyprotein + H2O
-
echovirus ?
-
?
enterovirus polyprotein + H2O
-
Mengo virus ?
-
?
enterovirus polyprotein + H2O
-
Theiler's encephalomyelitis virus ?
-
?
enterovirus polyprotein + H2O
-
picornaviridae ?
-
?
enterovirus polyprotein + H2O cleavage specificity enterovirus ?
-
?
histone protein H3 + H2O in BHK-cells, foot-and-mouth-disease virus enzyme Foot-and-mouth disease virus ?
-
?
peptides derived from polyprotein cleavage sites + H2O
-
enterovirus ?
-
?
picornavirus polyprotein + H2O
-
Foot-and-mouth disease virus hydrolyzed picornavirus polyprotein
-
?
picornavirus polyprotein + H2O
-
Enterovirus C hydrolyzed picornavirus polyprotein
-
?
picornavirus polyprotein + H2O
-
Encephalomyocarditis virus hydrolyzed picornavirus polyprotein
-
?
picornavirus polyprotein + H2O
-
enterovirus hydrolyzed picornavirus polyprotein
-
?
picornavirus polyprotein + H2O
-
Hepatovirus A hydrolyzed picornavirus polyprotein
-
?
picornavirus polyprotein + H2O
-
coxsackievirus hydrolyzed picornavirus polyprotein
-
?
picornavirus polyprotein + H2O
-
echovirus hydrolyzed picornavirus polyprotein
-
?
picornavirus polyprotein + H2O
-
Mengo virus hydrolyzed picornavirus polyprotein
-
?
picornavirus polyprotein + H2O
-
Theiler's encephalomyelitis virus hydrolyzed picornavirus polyprotein
-
?
picornavirus polyprotein + H2O
-
picornaviridae hydrolyzed picornavirus polyprotein
-
?
picornavirus polyprotein + H2O involved in proteolytic processing of virus polyprotein Foot-and-mouth disease virus hydrolyzed picornavirus polyprotein
-
?
picornavirus polyprotein + H2O involved in proteolytic processing of virus polyprotein Enterovirus C hydrolyzed picornavirus polyprotein
-
?
picornavirus polyprotein + H2O involved in proteolytic processing of virus polyprotein Encephalomyocarditis virus hydrolyzed picornavirus polyprotein
-
?
picornavirus polyprotein + H2O involved in proteolytic processing of virus polyprotein enterovirus hydrolyzed picornavirus polyprotein
-
?
picornavirus polyprotein + H2O involved in proteolytic processing of virus polyprotein Hepatovirus A hydrolyzed picornavirus polyprotein
-
?
picornavirus polyprotein + H2O involved in proteolytic processing of virus polyprotein coxsackievirus hydrolyzed picornavirus polyprotein
-
?
picornavirus polyprotein + H2O involved in proteolytic processing of virus polyprotein echovirus hydrolyzed picornavirus polyprotein
-
?
picornavirus polyprotein + H2O involved in proteolytic processing of virus polyprotein Mengo virus hydrolyzed picornavirus polyprotein
-
?
picornavirus polyprotein + H2O involved in proteolytic processing of virus polyprotein Theiler's encephalomyelitis virus hydrolyzed picornavirus polyprotein
-
?
picornavirus polyprotein + H2O involved in proteolytic processing of virus polyprotein picornaviridae hydrolyzed picornavirus polyprotein
-
?
poliovirus polyprotein + H2O initial cleavage at 2C-3A and 2B-2C, followed by 3A-3B and/or 3C-3D Enterovirus C hydrolyzed poliovirus polyprotein
-
?
rhinovirus polyprotein + H2O cleavage specificity enterovirus ?
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7 8
-
Enterovirus C
7 8
-
enterovirus