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Literature summary for 3.4.22.15 extracted from

  • Steverding, D.; Sexton, D.W.; Wang, X.; Gehrke, S.S.; Wagner, G.K.; Caffrey, C.R.
    Trypanosoma brucei: chemical evidence that cathepsin L is essential for survival and a relevant drug target (2012), Int. J. Parasitol., 42, 481-488.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(2S,3S)-oxirane-2,3-dicarboxylic acid 2-[((S)-1-benzylcarbamoyl-2-phenyl-ethyl)-amide] 3-[[2-(4-hydroxy-phenyl)-ethyl]-amide] specific inhibitor, CAA0225, more than 99% inhibition at 0.1 mM Trypanosoma brucei
(L-3-trans-propylcarbamoyloxirane-2-carbonyl)-L-isoleucyl-L-proline methyl ester CA-074Me, more than 99% inhibition at 0.1 mM Trypanosoma brucei
benzyloxycarbonyl-Phe-Arg-diazomethyl ketone more than 99% inhibition at 0.1 mM Trypanosoma brucei
L-3-trans-propylcarbamoyloxirane-2-carbonyl-L-isoleucyl-L-proline
-
Trypanosoma brucei

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O
-
Trypanosoma brucei benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
?

Synonyms

Synonyms Comment Organism
CatL
-
Trypanosoma brucei

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00022
-
at pH 5.0 and 22°C Trypanosoma brucei (2S,3S)-oxirane-2,3-dicarboxylic acid 2-[((S)-1-benzylcarbamoyl-2-phenyl-ethyl)-amide] 3-[[2-(4-hydroxy-phenyl)-ethyl]-amide]
0.1
-
IC50 above 0.1 mM, at pH 5.0 and 22°C Trypanosoma brucei L-3-trans-propylcarbamoyloxirane-2-carbonyl-L-isoleucyl-L-proline