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Literature summary for 3.4.22.15 extracted from

  • Torkar, A.; Lenarcic, B.; Lah, T.; Dive, V.; Devel, L.
    Identification of new peptide amides as selective cathepsin L inhibitors: the first step towards selective irreversible inhibitors? (2013), Bioorg. Med. Chem. Lett., 23, 2968-2973.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
benzyl [(2S)-1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-1-oxo-3-(1,1':4',1''-terphenyl-4-yl)propan-2-yl]carbamate
-
Homo sapiens
benzyl [(2S)-1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-3-(2'-methylbiphenyl-4-yl)-1-oxopropan-2-yl]carbamate
-
Homo sapiens
benzyl [(2S)-1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-3-(3'-methylbiphenyl-4-yl)-1-oxopropan-2-yl]carbamate
-
Homo sapiens
benzyl [(2S)-1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-3-(4'-methylbiphenyl-4-yl)-1-oxopropan-2-yl]carbamate
-
Homo sapiens
benzyl [(2S)-3-(3'-aminobiphenyl-4-yl)-1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-1-oxopropan-2-yl]carbamate
-
Homo sapiens
benzyl [(2S)-3-(3'-chlorobiphenyl-4-yl)-1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-1-oxopropan-2-yl]carbamate
-
Homo sapiens
benzyl [(2S)-3-(biphenyl-4-yl)-1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-1-oxopropan-2-yl]carbamate
-
Homo sapiens
N-(2,6-dimethylbenzoyl)-L-phenylalanyl-L-lysinamide
-
Homo sapiens
N-(2-chloro-5-nitrobenzoyl)-L-phenylalanyl-L-lysinamide
-
Homo sapiens
N-(3-phenylpropanoyl)-L-phenylalanyl-L-lysinamide
-
Homo sapiens
N-(4-bromobenzoyl)-L-phenylalanyl-L-lysinamide
-
Homo sapiens
N-(biphenyl-4-ylcarbonyl)-L-phenylalanyl-L-lysinamide
-
Homo sapiens
N-(cyclopent-1-en-1-ylcarbonyl)-L-phenylalanyl-L-lysinamide
-
Homo sapiens
N-(naphthalen-2-ylcarbonyl)-L-phenylalanyl-L-lysinamide
-
Homo sapiens
N-(pentafluorobenzoyl)-L-phenylalanyl-L-lysinamide
-
Homo sapiens
N-(piperidin-2-ylcarbonyl)-L-phenylalanyl-L-lysinamide
-
Homo sapiens
N-(pyridin-2-ylcarbonyl)-L-phenylalanyl-L-lysinamide
-
Homo sapiens
N-[(2R)-2-[(2-amino-2-oxoethyl)amino]-2-[[(benzyloxy)carbonyl]amino]acetyl]-L-phenylalanyl-L-lysinamide
-
Homo sapiens
N-[(2R)-2-[(3-aminopropyl)amino]-2-[[(benzyloxy)carbonyl]amino]acetyl]-L-phenylalanyl-L-lysinamide
-
Homo sapiens
N-[(2R)-2-[[(benzyloxy)carbonyl]amino]-2-(3a,7a-dihydro-1H-indol-3-ylamino)acetyl]-L-phenylalanyl-L-lysinamide
-
Homo sapiens
N-[(2R)-2-[[(benzyloxy)carbonyl]amino]-2-(propan-2-ylamino)acetyl]-L-phenylalanyl-L-lysinamide
-
Homo sapiens
N-[(2R)-2-[[(benzyloxy)carbonyl]amino]-2-[(2-carbamimidamidoethyl)amino]acetyl]-L-phenylalanyl-L-lysinamide
-
Homo sapiens
N-[(4'-carboxy-2,2'-bipyridin-4-yl)carbonyl]-L-phenylalanyl-L-lysinamide
-
Homo sapiens
N-[(6-aminopyridin-3-yl)carbonyl]-L-phenylalanyl-L-lysinamide
-
Homo sapiens
N-[(benzyloxy)carbonyl]-3-(1H-indazol-1-yl)-L-alanyl-L-lysinamide
-
Homo sapiens
N-[(benzyloxy)carbonyl]-3-(1H-indol-1-yl)-L-alanyl-L-lysinamide
-
Homo sapiens
N-[(benzyloxy)carbonyl]-4-(thiophen-2-yl)-L-phenylalanyl-L-lysinamide
-
Homo sapiens
N-[(benzyloxy)carbonyl]-L-leucyl-N-[(3S)-7-amino-1-[(2,6-dimethylbenzoyl)oxy]-2-oxoheptan-3-yl]-L-phenylalaninamide irreversible inhibitor Homo sapiens
N-[(benzyloxy)carbonyl]-L-phenylalanyl-3-(1H-imidazol-1-yl)-L-alaninamide
-
Homo sapiens
N-[(benzyloxy)carbonyl]-L-phenylalanyl-4-amino-L-phenylalaninamide
-
Homo sapiens
N-[(benzyloxy)carbonyl]-L-phenylalanyl-6-hydroxy-L-lysinamide
-
Homo sapiens
N-[(benzyloxy)carbonyl]-L-phenylalanyl-L-alaninamide
-
Homo sapiens
N-[(benzyloxy)carbonyl]-L-phenylalanyl-L-argininamide
-
Homo sapiens
N-[(benzyloxy)carbonyl]-L-phenylalanyl-L-leucinamide
-
Homo sapiens
N-[(benzyloxy)carbonyl]-L-phenylalanyl-L-lysinamide
-
Homo sapiens
N-[(benzyloxy)carbonyl]-L-phenylalanyl-L-methioninamide
-
Homo sapiens
N-[(benzyloxy)carbonyl]-L-phenylalanyl-L-ornithinamide
-
Homo sapiens
N-[(benzyloxy)carbonyl]-L-phenylalanyl-L-valinamide
-
Homo sapiens
N-[(benzyloxy)carbonyl]-L-phenylalanyl-N6-methyl-L-lysinamide
-
Homo sapiens
N-[(benzyloxy)carbonyl]-L-tryptophyl-N-[(3S)-7-amino-1-[(2,6-dimethylbenzoyl)oxy]-2-oxoheptan-3-yl]-L-phenylalaninamide irreversible inhibitor Homo sapiens
N-[(benzyloxy)carbonyl]-L-tyrosyl-L-lysinamide
-
Homo sapiens
N-[3-(4-hydroxyphenyl)propanoyl]-L-phenylalanyl-L-lysinamide
-
Homo sapiens
N-[3-(acetyloxy)benzoyl]-L-phenylalanyl-L-lysinamide
-
Homo sapiens
N-[4-(acetyloxy)benzoyl]-L-phenylalanyl-L-lysinamide
-
Homo sapiens
N-[4-(dimethylamino)benzoyl]-L-phenylalanyl-L-lysinamide
-
Homo sapiens
N-[4-(trifluoromethyl)benzoyl]-L-phenylalanyl-L-lysinamide
-
Homo sapiens
N2-acetyl-L-arginyl-L-lysyl-L-leucyl-L-leucyl-L-tryptophanamide potent inhibitor Homo sapiens
N2-[(benzyloxy)carbonyl]-L-arginyl-N-[(3S)-7-amino-1-[(2,6-dimethylbenzoyl)oxy]-2-oxoheptan-3-yl]-L-phenylalaninamide irreversible inhibitor Homo sapiens
N2-[(benzyloxy)carbonyl]-L-ornithyl-N-[(3S)-7-amino-1-[(2,6-dimethylbenzoyl)oxy]-2-oxoheptan-3-yl]-L-phenylalaninamide irreversible inhibitor Homo sapiens
Nalpha-[(benzyloxy)carbonyl]-N-[(1R)-1,2-diamino-2-oxoethyl]-L-phenylalaninamide
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Cbz-Phe-Arg-7-amido-4-methylcoumarin + H2O
-
Homo sapiens Cbz-Phe-Arg + 7-amino-4-methylcoumarin
-
?

Synonyms

Synonyms Comment Organism
CatL
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00012
-
N-[(benzyloxy)carbonyl]-4-(thiophen-2-yl)-L-phenylalanyl-L-lysinamide 100 mM phosphate buffer, pH 6.0, 2 mM EDTA, temperature not specified in the publication Homo sapiens
0.00039
-
N-[(2R)-2-[[(benzyloxy)carbonyl]amino]-2-(3a,7a-dihydro-1H-indol-3-ylamino)acetyl]-L-phenylalanyl-L-lysinamide 100 mM phosphate buffer, pH 6.0, 2 mM EDTA, temperature not specified in the publication Homo sapiens
0.00045
-
N-[(2R)-2-[[(benzyloxy)carbonyl]amino]-2-(propan-2-ylamino)acetyl]-L-phenylalanyl-L-lysinamide 100 mM phosphate buffer, pH 6.0, 2 mM EDTA, temperature not specified in the publication Homo sapiens
0.00074
-
N-[(2R)-2-[[(benzyloxy)carbonyl]amino]-2-[(2-carbamimidamidoethyl)amino]acetyl]-L-phenylalanyl-L-lysinamide 100 mM phosphate buffer, pH 6.0, 2 mM EDTA, temperature not specified in the publication Homo sapiens
0.00089
-
N-[(2R)-2-[(3-aminopropyl)amino]-2-[[(benzyloxy)carbonyl]amino]acetyl]-L-phenylalanyl-L-lysinamide 100 mM phosphate buffer, pH 6.0, 2 mM EDTA, temperature not specified in the publication Homo sapiens
0.001
-
N-[4-(trifluoromethyl)benzoyl]-L-phenylalanyl-L-lysinamide 100 mM phosphate buffer, pH 6.0, 2 mM EDTA, temperature not specified in the publication Homo sapiens
0.001
-
N-(naphthalen-2-ylcarbonyl)-L-phenylalanyl-L-lysinamide 100 mM phosphate buffer, pH 6.0, 2 mM EDTA, temperature not specified in the publication Homo sapiens
0.0014
-
N-[(benzyloxy)carbonyl]-L-tyrosyl-L-lysinamide 100 mM phosphate buffer, pH 6.0, 2 mM EDTA, temperature not specified in the publication Homo sapiens
0.0017
-
benzyl [(2S)-3-(3'-chlorobiphenyl-4-yl)-1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-1-oxopropan-2-yl]carbamate 100 mM phosphate buffer, pH 6.0, 2 mM EDTA, temperature not specified in the publication Homo sapiens
0.0017
-
benzyl [(2S)-1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-3-(4'-methylbiphenyl-4-yl)-1-oxopropan-2-yl]carbamate 100 mM phosphate buffer, pH 6.0, 2 mM EDTA, temperature not specified in the publication Homo sapiens
0.0018
-
benzyl [(2S)-3-(3'-aminobiphenyl-4-yl)-1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-1-oxopropan-2-yl]carbamate 100 mM phosphate buffer, pH 6.0, 2 mM EDTA, temperature not specified in the publication Homo sapiens
0.0023
-
N-(4-bromobenzoyl)-L-phenylalanyl-L-lysinamide 100 mM phosphate buffer, pH 6.0, 2 mM EDTA, temperature not specified in the publication Homo sapiens
0.0024
-
benzyl [(2S)-3-(biphenyl-4-yl)-1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-1-oxopropan-2-yl]carbamate 100 mM phosphate buffer, pH 6.0, 2 mM EDTA, temperature not specified in the publication Homo sapiens
0.0024
-
N-[3-(acetyloxy)benzoyl]-L-phenylalanyl-L-lysinamide 100 mM phosphate buffer, pH 6.0, 2 mM EDTA, temperature not specified in the publication Homo sapiens
0.0025
-
benzyl [(2S)-1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-3-(3'-methylbiphenyl-4-yl)-1-oxopropan-2-yl]carbamate 100 mM phosphate buffer, pH 6.0, 2 mM EDTA, temperature not specified in the publication Homo sapiens
0.0025
-
N-[3-(4-hydroxyphenyl)propanoyl]-L-phenylalanyl-L-lysinamide 100 mM phosphate buffer, pH 6.0, 2 mM EDTA, temperature not specified in the publication Homo sapiens
0.0026
-
N-[(benzyloxy)carbonyl]-L-phenylalanyl-N6-methyl-L-lysinamide 100 mM phosphate buffer, pH 6.0, 2 mM EDTA, temperature not specified in the publication Homo sapiens
0.0026
-
benzyl [(2S)-1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-1-oxo-3-(1,1':4',1''-terphenyl-4-yl)propan-2-yl]carbamate 100 mM phosphate buffer, pH 6.0, 2 mM EDTA, temperature not specified in the publication Homo sapiens
0.0026
-
N-[4-(acetyloxy)benzoyl]-L-phenylalanyl-L-lysinamide 100 mM phosphate buffer, pH 6.0, 2 mM EDTA, temperature not specified in the publication Homo sapiens
0.0027
-
N-(2-chloro-5-nitrobenzoyl)-L-phenylalanyl-L-lysinamide 100 mM phosphate buffer, pH 6.0, 2 mM EDTA, temperature not specified in the publication Homo sapiens
0.0029
-
N-[4-(dimethylamino)benzoyl]-L-phenylalanyl-L-lysinamide 100 mM phosphate buffer, pH 6.0, 2 mM EDTA, temperature not specified in the publication Homo sapiens
0.0031
-
N-[(benzyloxy)carbonyl]-3-(1H-indazol-1-yl)-L-alanyl-L-lysinamide 100 mM phosphate buffer, pH 6.0, 2 mM EDTA, temperature not specified in the publication Homo sapiens
0.0032
-
N-(3-phenylpropanoyl)-L-phenylalanyl-L-lysinamide 100 mM phosphate buffer, pH 6.0, 2 mM EDTA, temperature not specified in the publication Homo sapiens
0.0035
-
N-[(benzyloxy)carbonyl]-L-phenylalanyl-L-ornithinamide 100 mM phosphate buffer, pH 6.0, 2 mM EDTA, temperature not specified in the publication Homo sapiens
0.0042
-
N-[(benzyloxy)carbonyl]-L-phenylalanyl-L-lysinamide 100 mM phosphate buffer, pH 6.0, 2 mM EDTA, temperature not specified in the publication Homo sapiens
0.0042
-
N-[(benzyloxy)carbonyl]-3-(1H-indol-1-yl)-L-alanyl-L-lysinamide 100 mM phosphate buffer, pH 6.0, 2 mM EDTA, temperature not specified in the publication Homo sapiens
0.0046
-
N-[(4'-carboxy-2,2'-bipyridin-4-yl)carbonyl]-L-phenylalanyl-L-lysinamide 100 mM phosphate buffer, pH 6.0, 2 mM EDTA, temperature not specified in the publication Homo sapiens
0.005
-
N-[(6-aminopyridin-3-yl)carbonyl]-L-phenylalanyl-L-lysinamide 100 mM phosphate buffer, pH 6.0, 2 mM EDTA, temperature not specified in the publication Homo sapiens
0.0055
-
N-(pyridin-2-ylcarbonyl)-L-phenylalanyl-L-lysinamide 100 mM phosphate buffer, pH 6.0, 2 mM EDTA, temperature not specified in the publication Homo sapiens
0.0061
-
N-(piperidin-2-ylcarbonyl)-L-phenylalanyl-L-lysinamide 100 mM phosphate buffer, pH 6.0, 2 mM EDTA, temperature not specified in the publication Homo sapiens
0.0068
-
N-(pentafluorobenzoyl)-L-phenylalanyl-L-lysinamide 100 mM phosphate buffer, pH 6.0, 2 mM EDTA, temperature not specified in the publication Homo sapiens
0.007
-
N-[(2R)-2-[(2-amino-2-oxoethyl)amino]-2-[[(benzyloxy)carbonyl]amino]acetyl]-L-phenylalanyl-L-lysinamide 100 mM phosphate buffer, pH 6.0, 2 mM EDTA, temperature not specified in the publication Homo sapiens
0.0078
-
N-(cyclopent-1-en-1-ylcarbonyl)-L-phenylalanyl-L-lysinamide 100 mM phosphate buffer, pH 6.0, 2 mM EDTA, temperature not specified in the publication Homo sapiens
0.009
-
N-(biphenyl-4-ylcarbonyl)-L-phenylalanyl-L-lysinamide 100 mM phosphate buffer, pH 6.0, 2 mM EDTA, temperature not specified in the publication Homo sapiens
0.014
-
N-[(benzyloxy)carbonyl]-L-phenylalanyl-3-(1H-imidazol-1-yl)-L-alaninamide 100 mM phosphate buffer, pH 6.0, 2 mM EDTA, temperature not specified in the publication Homo sapiens
0.014
-
N-[(benzyloxy)carbonyl]-L-phenylalanyl-L-leucinamide 100 mM phosphate buffer, pH 6.0, 2 mM EDTA, temperature not specified in the publication Homo sapiens
0.016
-
N-[(benzyloxy)carbonyl]-L-phenylalanyl-L-alaninamide 100 mM phosphate buffer, pH 6.0, 2 mM EDTA, temperature not specified in the publication Homo sapiens
0.017
-
N-[(benzyloxy)carbonyl]-L-phenylalanyl-L-valinamide 100 mM phosphate buffer, pH 6.0, 2 mM EDTA, temperature not specified in the publication Homo sapiens
0.02
-
N-(2,6-dimethylbenzoyl)-L-phenylalanyl-L-lysinamide 100 mM phosphate buffer, pH 6.0, 2 mM EDTA, temperature not specified in the publication Homo sapiens
0.023
-
benzyl [(2S)-1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-3-(2'-methylbiphenyl-4-yl)-1-oxopropan-2-yl]carbamate 100 mM phosphate buffer, pH 6.0, 2 mM EDTA, temperature not specified in the publication Homo sapiens
0.026
-
N-[(benzyloxy)carbonyl]-L-phenylalanyl-4-amino-L-phenylalaninamide 100 mM phosphate buffer, pH 6.0, 2 mM EDTA, temperature not specified in the publication Homo sapiens
0.027
-
N-[(benzyloxy)carbonyl]-L-phenylalanyl-6-hydroxy-L-lysinamide 100 mM phosphate buffer, pH 6.0, 2 mM EDTA, temperature not specified in the publication Homo sapiens
0.028
-
Nalpha-[(benzyloxy)carbonyl]-N-[(1R)-1,2-diamino-2-oxoethyl]-L-phenylalaninamide 100 mM phosphate buffer, pH 6.0, 2 mM EDTA, temperature not specified in the publication Homo sapiens
0.028
-
N-[(benzyloxy)carbonyl]-L-phenylalanyl-L-argininamide 100 mM phosphate buffer, pH 6.0, 2 mM EDTA, temperature not specified in the publication Homo sapiens
0.064
-
N-[(benzyloxy)carbonyl]-L-phenylalanyl-L-methioninamide 100 mM phosphate buffer, pH 6.0, 2 mM EDTA, temperature not specified in the publication Homo sapiens