Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Mus musculus | 5764 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
keratinocyte | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
CTSL | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | deficiency for cathepsin L promotes enhanced tumor progression and metastasis in mouse epidermis, Ctsl deficiency potentiates neoplastic progression in K14-HPV16 transgenic mice but does not alter immune cell infiltration or angiogenesis during neoplastic progression in HPV16 mice | Mus musculus |
physiological function | Ctsl is critical for the termination of growth factor signaling in the endosomal/lysosomal compartment of keratinocytes and, therefore, functions as an anti-tumor protease | Mus musculus |