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Literature summary for 3.4.22.15 extracted from

  • Dennemaerker, J.; Lohmueller, T.; Mayerle, J.; Tacke, M.; Lerch, M.M.; Coussens, L.M.; Peters, C.; Reinheckel, T.
    Deficiency for the cysteine protease cathepsin L promotes tumor progression in mouse epidermis (2010), Oncogene, 29, 1611-1621.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
Mus musculus 5764
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
keratinocyte
-
Mus musculus
-

Synonyms

Synonyms Comment Organism
CTSL
-
Mus musculus

General Information

General Information Comment Organism
malfunction deficiency for cathepsin L promotes enhanced tumor progression and metastasis in mouse epidermis, Ctsl deficiency potentiates neoplastic progression in K14-HPV16 transgenic mice but does not alter immune cell infiltration or angiogenesis during neoplastic progression in HPV16 mice Mus musculus
physiological function Ctsl is critical for the termination of growth factor signaling in the endosomal/lysosomal compartment of keratinocytes and, therefore, functions as an anti-tumor protease Mus musculus