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Literature summary for 3.4.22.15 extracted from

  • Puchi, M.; Garcia-Huidobro, J.; Cordova, C.; Aguilar, R.; Dufey, E.; Imschenetzky, M.; Bustos, P.; Morin, V.
    A new nuclear protease with cathepsin L properties is present in Hela and Caco-2 cells (2010), J. Cell. Biochem., 111, 1099-1106.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
benzyloxycarbonyl-L-Phe-L-Phe-fluoromethylketone
-
Homo sapiens
E-64d
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm the protease translocates to the cytoplasm in non proliferative cells Homo sapiens 5737
-
nucleus the protease associates to the mitotic spindle during mitosis and remains in the nuclei in binuclear cells Homo sapiens 5634
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
60000
-
SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
histone H1 + H2O Homo sapiens
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial purification by Superdex-75 gel filtration Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
Caco-2 cell
-
Homo sapiens
-
HeLa cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzyloxycarbonyl-L-Phe-L-Arg-7-amido-4-methylcoumarin + H2O
-
Homo sapiens benzyloxycarbonyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin
-
?
histone H1 + H2O
-
Homo sapiens ?
-
?