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Literature summary for 3.4.22.15 extracted from

  • Kishore Kumar, G.D.; Chavarria, G.E.; Charlton-Sevcik, A.K.; Arispe, W.M.; Macdonough, M.T.; Strecker, T.E.; Chen, S.E.; Siim, B.G.; Chaplin, D.J.; Trawick, M.L.; Pinney, K.G.
    Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors (2010), Bioorg. Med. Chem. Lett., 20, 1415-1419.
    View publication on PubMed
Search for more literature for 3.4.22.15

Inhibitors

Inhibitors Comment Organism Structure
(2E)-2-(7-bromo-3,4-dihydronaphthalen-1(2H)-ylidene)hydrazinecarbothioamide
-
 Homo sapiens
(2E)-2-[(2-fluorophenyl)(4-fluorophenyl)methylidene]hydrazinecarbothioamide
-
 Homo sapiens
(2E)-2-[(3-bromophenyl)(3,4,5-trifluorophenyl)methylidene]hydrazinecarbothioamide
-
 Homo sapiens
(2E)-2-[(3-bromophenyl)(3,5-dichlorophenyl)methylidene]hydrazinecarbothioamide
-
 Homo sapiens
(2E)-2-[(3-bromophenyl)(3,5-difluorophenyl)methylidene]hydrazinecarbothioamide
-
 Homo sapiens
(2E)-2-[(3-bromophenyl)(3-chlorophenyl)methylidene]hydrazinecarbothioamide
-
 Homo sapiens
(2E)-2-[(3-bromophenyl)(3-fluorophenyl)methylidene]hydrazinecarbothioamide
-
 Homo sapiens
(2E)-2-[(3-bromophenyl)(3-methylphenyl)methylidene]hydrazinecarbothioamide
-
 Homo sapiens
(2E)-2-[(3-bromophenyl)(4-bromophenyl)methylidene]hydrazinecarbothioamide
-
 Homo sapiens
(2E)-2-[(3-bromophenyl)(4-chlorophenyl)methylidene]hydrazinecarbothioamide
-
 Homo sapiens
(2E)-2-[(3-bromophenyl)(4-fluorophenyl)methylidene]hydrazinecarbothioamide
-
 Homo sapiens
(2E)-2-[(3-bromophenyl)(4-methylphenyl)methylidene]hydrazinecarbothioamide
-
 Homo sapiens
(2E)-2-[(3-bromophenyl)[3-(trifluoromethyl)phenyl]methylidene]hydrazinecarbothioamide
-
 Homo sapiens
(2E)-2-[(3-bromophenyl)[4-(trifluoromethyl)phenyl]methylidene]hydrazinecarbothioamide
-
 Homo sapiens
(2E)-2-[(4-bromophenyl)(4-chlorophenyl)methylidene]hydrazinecarbothioamide
-
 Homo sapiens
(2E)-2-[(4-bromophenyl)(4-fluorophenyl)methylidene]hydrazinecarbothioamide
-
 Homo sapiens
(2E)-2-[(4-bromophenyl)(4-methylphenyl)methylidene]hydrazinecarbothioamide
-
 Homo sapiens
(2E)-2-[(4-bromophenyl)[4-(trifluoromethyl)phenyl]methylidene]hydrazinecarbothioamide
-
 Homo sapiens
(2E)-2-[[3,5-bis(trifluoromethyl)phenyl](3-bromophenyl)methylidene]hydrazinecarbothioamide
-
 Homo sapiens
(2S,3S)-3-([(2S)-1-[(8-carbamimidamidooctyl)amino]-4-methyl-1-oxopentan-2-yl]carbamoyl)oxirane-2-carboxylic acid
-
 Homo sapiens
(2Z)-2-[(2-bromophenyl)(3-bromophenyl)methylidene]hydrazinecarbothioamide
-
 Homo sapiens
(2Z)-2-[(2-bromophenyl)(4-bromophenyl)methylidene]hydrazinecarbothioamide
-
 Homo sapiens
(2Z)-2-[(2-fluorophenyl)(phenyl)methylidene]hydrazinecarbothioamide
-
 Homo sapiens
(2Z)-2-[(3-bromo-2-fluorophenyl)(3-bromophenyl)methylidene]hydrazinecarbothioamide
-
 Homo sapiens
(2Z)-2-[(3-bromo-4-fluorophenyl)(3-bromophenyl)methylidene]hydrazinecarbothioamide
-
 Homo sapiens
(2Z)-2-[(3-bromophenyl)(2,3,4,5-tetrafluorophenyl)methylidene]hydrazinecarbothioamide
-
 Homo sapiens
(2Z)-2-[(3-bromophenyl)(2,3-difluorophenyl)methylidene]hydrazinecarbothioamide
-
 Homo sapiens
(2Z)-2-[(3-bromophenyl)(2,6-difluorophenyl)methylidene]hydrazinecarbothioamide
-
 Homo sapiens
(2Z)-2-[(3-bromophenyl)(2-chlorophenyl)methylidene]hydrazinecarbothioamide
-
 Homo sapiens
(2Z)-2-[(3-bromophenyl)(2-fluorophenyl)methylidene]hydrazinecarbothioamide
-
 Homo sapiens
(2Z)-2-[(3-bromophenyl)(2-methylphenyl)methylidene]hydrazinecarbothioamide
-
 Homo sapiens
(2Z)-2-[(4-bromophenyl)(2-fluorophenyl)methylidene]hydrazinecarbothioamide
-
 Homo sapiens
(2Z)-2-[[3,5-bis(trifluoromethyl)phenyl](4-methylphenyl)methylidene]hydrazinecarbothioamide
-
 Homo sapiens
2-[bis(3-bromophenyl)methylidene]-N-ethylhydrazinecarbothioamide
-
 Homo sapiens
2-[bis(3-bromophenyl)methylidene]-N-phenylhydrazinecarbothioamide
-
 Homo sapiens
2-[bis(3-fluorophenyl)methylidene]hydrazinecarbothioamide
-
 Homo sapiens
2-[bis(4-bromophenyl)methylidene]hydrazinecarbothioamide
-
 Homo sapiens
2-[bis(4-fluorophenyl)methylidene]hydrazinecarbothioamide
-
 Homo sapiens
N-(1-cyanopyrrolidin-3-yl)benzenesulfonamide
-
 Homo sapiens
N-benzyl-2-[bis(3-bromophenyl)methylidene]hydrazinecarbothioamide
-
 Homo sapiens
N-[(2S)-1-(1H-indol-3-yl)-3-oxopropan-2-yl]-N2-(naphthalen-1-ylsulfonyl)-L-isoleucinamide
-
 Homo sapiens
N-[(2S)-1-(3-chlorophenyl)-3-[(cyanomethyl)amino]but-3-en-2-yl]benzamide
-
 Homo sapiens
N-[(2S)-4-methyl-1-oxo-1-[[(4S)-3-oxo-1-(pyridin-2-ylsulfonyl)azepan-4-yl]amino]pentan-2-yl]-1-benzofuran-2-carboxamide
-
 Homo sapiens
N2-[(benzyloxy)carbonyl]-N-[(3S)-1-cyanopyrrolidin-3-yl]-L-leucinamide
-
 Homo sapiens
S-[2-[(2-ethylphenyl)amino]-2-oxoethyl] 2-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-(1H-indol-3-yl)propanoyl]hydrazinecarbothioate
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
DU-145 cell
-
 Homo sapiens
-
prostate cancer cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
cat L
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000305
-
 pH and temperature not specified in the publication Homo sapiens (2Z)-2-[(3-bromophenyl)(2-fluorophenyl)methylidene]hydrazinecarbothioamide
0.0000465
-
 pH and temperature not specified in the publication Homo sapiens (2E)-2-[(3-bromophenyl)[3-(trifluoromethyl)phenyl]methylidene]hydrazinecarbothioamide
0.0000594
-
 pH and temperature not specified in the publication Homo sapiens (2E)-2-[(3-bromophenyl)(3,5-difluorophenyl)methylidene]hydrazinecarbothioamide
0.0000632
-
 pH and temperature not specified in the publication Homo sapiens (2Z)-2-[(3-bromophenyl)(2,3,4,5-tetrafluorophenyl)methylidene]hydrazinecarbothioamide
0.0000796
-
 pH and temperature not specified in the publication Homo sapiens (2E)-2-[(3-bromophenyl)(4-fluorophenyl)methylidene]hydrazinecarbothioamide
0.0000838
-
 pH and temperature not specified in the publication Homo sapiens (2Z)-2-[(3-bromophenyl)(2,3-difluorophenyl)methylidene]hydrazinecarbothioamide
0.000096
-
 pH and temperature not specified in the publication Homo sapiens (2E)-2-[[3,5-bis(trifluoromethyl)phenyl](3-bromophenyl)methylidene]hydrazinecarbothioamide
0.000114
-
 pH and temperature not specified in the publication Homo sapiens (2Z)-2-[(3-bromo-4-fluorophenyl)(3-bromophenyl)methylidene]hydrazinecarbothioamide
0.000118
-
 pH and temperature not specified in the publication Homo sapiens (2E)-2-[(3-bromophenyl)(3,4,5-trifluorophenyl)methylidene]hydrazinecarbothioamide
0.000131
-
 pH and temperature not specified in the publication Homo sapiens (2E)-2-[(3-bromophenyl)(3-chlorophenyl)methylidene]hydrazinecarbothioamide
0.000224
-
 pH and temperature not specified in the publication Homo sapiens (2E)-2-[(3-bromophenyl)(3-methylphenyl)methylidene]hydrazinecarbothioamide
0.000233
-
 pH and temperature not specified in the publication Homo sapiens (2Z)-2-[(3-bromo-2-fluorophenyl)(3-bromophenyl)methylidene]hydrazinecarbothioamide
0.00025
-
 pH and temperature not specified in the publication Homo sapiens (2E)-2-[(3-bromophenyl)(3-fluorophenyl)methylidene]hydrazinecarbothioamide
0.000327
-
 pH and temperature not specified in the publication Homo sapiens (2E)-2-[(3-bromophenyl)(4-chlorophenyl)methylidene]hydrazinecarbothioamide
0.000415
-
 pH and temperature not specified in the publication Homo sapiens (2E)-2-[(3-bromophenyl)(3,5-dichlorophenyl)methylidene]hydrazinecarbothioamide
0.000521
-
 pH and temperature not specified in the publication Homo sapiens (2E)-2-[(3-bromophenyl)[4-(trifluoromethyl)phenyl]methylidene]hydrazinecarbothioamide
0.00061
-
 pH and temperature not specified in the publication Homo sapiens (2Z)-2-[(3-bromophenyl)(2,6-difluorophenyl)methylidene]hydrazinecarbothioamide
0.00161
-
 pH and temperature not specified in the publication Homo sapiens (2Z)-2-[(3-bromophenyl)(2-chlorophenyl)methylidene]hydrazinecarbothioamide
0.00216
-
 pH and temperature not specified in the publication Homo sapiens (2E)-2-[(3-bromophenyl)(4-methylphenyl)methylidene]hydrazinecarbothioamide
0.00222
-
 pH and temperature not specified in the publication Homo sapiens (2Z)-2-[(4-bromophenyl)(2-fluorophenyl)methylidene]hydrazinecarbothioamide
0.00246
-
 pH and temperature not specified in the publication Homo sapiens (2E)-2-[(2-fluorophenyl)(4-fluorophenyl)methylidene]hydrazinecarbothioamide
0.0026
-
 pH and temperature not specified in the publication Homo sapiens (2Z)-2-[(2-bromophenyl)(3-bromophenyl)methylidene]hydrazinecarbothioamide
0.00332
-
 pH and temperature not specified in the publication Homo sapiens (2E)-2-[(4-bromophenyl)(4-fluorophenyl)methylidene]hydrazinecarbothioamide
0.00457
-
 pH and temperature not specified in the publication Homo sapiens (2E)-2-[(4-bromophenyl)(4-methylphenyl)methylidene]hydrazinecarbothioamide
0.00487
-
 pH and temperature not specified in the publication Homo sapiens 2-[bis(3-fluorophenyl)methylidene]hydrazinecarbothioamide
0.01
-
 IC50 above 0.01 mM, pH and temperature not specified in the publication Homo sapiens (2Z)-2-[(2-bromophenyl)(4-bromophenyl)methylidene]hydrazinecarbothioamide
0.01
-
 IC50 above 0.01 mM, pH and temperature not specified in the publication Homo sapiens N-benzyl-2-[bis(3-bromophenyl)methylidene]hydrazinecarbothioamide
0.01
-
 IC50 above 0.01 mM, pH and temperature not specified in the publication Homo sapiens 2-[bis(4-bromophenyl)methylidene]hydrazinecarbothioamide
0.01
-
 IC50 above 0.01 mM, pH and temperature not specified in the publication Homo sapiens (2E)-2-[(4-bromophenyl)[4-(trifluoromethyl)phenyl]methylidene]hydrazinecarbothioamide
0.01
-
 IC50 above 0.01 mM, pH and temperature not specified in the publication Homo sapiens 2-[bis(3-bromophenyl)methylidene]-N-ethylhydrazinecarbothioamide
0.01
-
 IC50 above 0.01 mM, pH and temperature not specified in the publication Homo sapiens (2Z)-2-[(2-fluorophenyl)(phenyl)methylidene]hydrazinecarbothioamide
0.01
-
 IC50 above 0.01 mM, pH and temperature not specified in the publication Homo sapiens (2Z)-2-[(3-bromophenyl)(2-methylphenyl)methylidene]hydrazinecarbothioamide
0.01
-
 IC50 above 0.01 mM, pH and temperature not specified in the publication Homo sapiens (2E)-2-[(3-bromophenyl)(4-bromophenyl)methylidene]hydrazinecarbothioamide
0.01
-
 IC50 above 0.01 mM, pH and temperature not specified in the publication Homo sapiens 2-[bis(4-fluorophenyl)methylidene]hydrazinecarbothioamide
0.01
-
 IC50 above 0.01 mM, pH and temperature not specified in the publication Homo sapiens (2E)-2-[(4-bromophenyl)(4-chlorophenyl)methylidene]hydrazinecarbothioamide
0.01
-
 IC50 above 0.01 mM, pH and temperature not specified in the publication Homo sapiens 2-[bis(3-bromophenyl)methylidene]-N-phenylhydrazinecarbothioamide