Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of cell lines with reduced expression of cathepsin L by stable transfection of H-59 cells with a plasmid expressing an antisense fragment of mouse cathepsin L cDNA. Transfected cells show a loss of IGF-I-induced receptor phosphorylation and Shc recruitment, reduced IGF-I (but not IGFII)-induced cellular proliferation and migration, decreased anchorage-independent growth and reduced plasma membrane levels of IGF type I receptor. Changes result in apoptosis in vivo and an impaired ability to form liver metastases | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | cathepsin L expression levels regulate cell responsiveness to IGF-type I, function for cathepsin L in the control of the tumorigenic/metastatic phenotype | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
H-59 cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | cathepsin L expression levels regulate cell responsiveness to IGF-type I, function for cathepsin L in the control of the tumorigenic/metastatic phenotype | Mus musculus | ? | - |
? |