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Literature summary for 3.4.22.15 extracted from
- Activation of cathepsin L by the cathelin-like domain of protegrin-3 (2008), Mol. Immunol., 45, 2531-2536.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| protegrin-3 | a porcine cathelicidin, molecular weight 11.7 kDa. The cathelin-like domain efficiently activates human cathepsin L. Partial deletion of the L2 loop of cathelin-like domain, a structurally equivalent region important ininteraction of cystatins with proteases, significantly decreases its activating effect on cathepsin L. Proposal of a complex model based on this functional loop, with the cathelin-like domain fitting into the active cleft of the enzyme in an analogous way as cystatin B does | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| commercial preparation | isolated from liver | Homo sapiens | - |
| liver | commercial production | Homo sapiens | - |
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