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Literature summary for 3.4.22.15 extracted from
- Cathepsin L expression is up-regulated by hypoxia in human melanoma cells: role of its 5-untranslated region (2008), Biochem. J., 413, 125-134.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | under moderate hypoxic conditions of 1% O2, intracellular expression of cathepsin L is up-regulated. Hypoxia significantly increases only the expression of the transcript which contains the complete internal ribosome entry site, but inhibits promoter activity | Homo sapiens |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | in vivo a tumor hypoxic environment up-regulates cathepsin L expression which promotes tumor progression | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| A-375SM cell | - |
Homo sapiens | - |
| DM-4 cell | - |
Homo sapiens | - |
| melanoma cell | - |
Homo sapiens | - |
| NCI-H1299 cell | - |
Homo sapiens | - |
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Release 2023.1 (January 2023)
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