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Literature summary for 3.4.22.15 extracted from

  • Stack, C.M.; Caffrey, C.R.; Donnelly, S.M.; Seshaadri, A.; Lowther, J.; Tort, J.F.; Collins, P.R.; Robinson, M.W.; Xu, W.; McKerrow, J.H.; Craik, C.S.; Geiger, S.R.; Marion, R.; Brinen, L.S.; Dalton, J.P.
    Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, Fasciola hepatica (2008), J. Biol. Chem., 283, 9896-9908.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining

Source Tissue

Source Tissue Comment Organism Textmining

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.17
-
 tosyl-Gly-Pro-Arg-7-amido-4-methylcoumarin wild type enzyme FehCL2, in PBS, pH 7.3, and 100 mM sodium acetate buffer, pH 5.5, each containing 2.5 mM dithiothreitol and 2.5 mM EDTA Fasciola hepatica
1.62
-
 benzyloxycarbonyl-Leu-Arg-7-amido-4-methylcoumarin wild type enzyme FehCL2, in PBS, pH 7.3, and 100 mM sodium acetate buffer, pH 5.5, each containing 2.5 mM dithiothreitol and 2.5 mM EDTA Fasciola hepatica
1.7
-
 benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin wild type enzyme FehCL2, in PBS, pH 7.3, and 100 mM sodium acetate buffer, pH 5.5, each containing 2.5 mM dithiothreitol and 2.5 mM EDTA Fasciola hepatica
2.48
-
 tert-butyloxycarbonyl-Ala-Gly-Pro-Arg-7-amido-4-methylcoumarin wild type enzyme FehCL2, in PBS, pH 7.3, and 100 mM sodium acetate buffer, pH 5.5, each containing 2.5 mM dithiothreitol and 2.5 mM EDTA Fasciola hepatica
2.64
-
 benzyloxycarbonyl-Pro-Arg-7-amido-4-methylcoumarin wild type enzyme FehCL2, in PBS, pH 7.3, and 100 mM sodium acetate buffer, pH 5.5, each containing 2.5 mM dithiothreitol and 2.5 mM EDTA Fasciola hepatica