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Literature summary for 3.4.22.15 extracted from
- Cathepsin L plays an important role in the lysosomal degradation of L-lactate dehydrogenase (2006), Biosci. Biotechnol. Biochem., 70, 2254-2261.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (L-3-trans-carboxyoxirane-2-carbonyl)-L-leucine(3-methylbutyl)-amide | 0.01 mg/ml | Rattus norvegicus |  |
| cystatin alpha | 0.05 mg/ml | Rattus norvegicus | |
| leupeptin | 0.1 mg/ml | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| lysosome | - |
Rattus norvegicus | 5764 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 24000 | - |
SDS-PAGE | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Sephacryl S200 gel filtration and CM-Sephadex gel filtration | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O | - |
Rattus norvegicus | benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin | - |
? | |
| L-lactate dehydrogenase + H2O | - |
Rattus norvegicus | ? | - |
? | |
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Release 2023.1 (January 2023)
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