Literature summary for 3.4.22.15 extracted from

Marquis, R.W.; James, I.; Zeng, J.; Trout, R.E.; Thompson, S.; Rahman, A.; Yamashita, D.S.; Xie, R.; Ru, Y.; Gress, C.J.; Blake, S.; Lark, M.A.; Hwang, S.M.; Tomaszek, T.; Offen, P.; Head, M.S.; Cummings, M.D.; Veber, D.F.
Azepanone-based inhibitors of human cathepsin L (2005), J. Med. Chem., 48, 6870-6878.

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Inhibitors

Inhibitors	Comment	Organism	Structure
azepanone	-	Homo sapiens
benzofuran-2-carboxylic acid ((S)-1-[3-oxo-1-(pyridine-2-sulfonyl)azepan-4-ylcarbamoyl]-2-naphthylen-2-yl)amide	-	Homo sapiens
benzofuran-2-carboxylic acid ((S)-1-[3-oxo-1-(pyridine-2-sulfonyl)azepan-4-ylcarbamoyl]-2-phenyl-ethyl)amide	-	Homo sapiens
naphthalene-2-carboxylic acid ((S)-2-naphthalen-2-yl-1-[(S)-3-oxo-1-(pyridine-2-sulfonyl)azepan-4-ylcarbamoyl]ethyl)amide	-	Homo sapiens
naphthoic-1-carboxylic acid ((S)-1-[3-oxo-1-(pyridine-2-sulfonyl)azepan-4-ylcarbamoyl]-3-methyl-butyl)amide	-	Homo sapiens
quinoline-2-carboxylic acid ((S)-1-[3-oxo-1-(pyridine-2-sulfonyl)azepan-4-ylcarbamoyl]-3-methyl-butyl)amide	-	Homo sapiens
quinoline-8-carboxylic acid ((S)-1-[3-oxo-1-(pyridine-2-sulfonyl)azepan-4-ylcarbamoyl]-3-methyl-butyl)amide	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
cathepsin L	-	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00000043	-	naphthalene-2-carboxylic acid ((S)-2-naphthalen-2-yl-1-[(S)-3-oxo-1-(pyridine-2-sulfonyl)azepan-4-ylcarbamoyl]ethyl)amide	-	Homo sapiens
0.00000057	-	benzofuran-2-carboxylic acid ((S)-1-[3-oxo-1-(pyridine-2-sulfonyl)azepan-4-ylcarbamoyl]-2-naphthylen-2-yl)amide	-	Homo sapiens
0.0000014	-	naphthoic-1-carboxylic acid ((S)-1-[3-oxo-1-(pyridine-2-sulfonyl)azepan-4-ylcarbamoyl]-3-methyl-butyl)amide	-	Homo sapiens
0.0000017	-	benzofuran-2-carboxylic acid ((S)-1-[3-oxo-1-(pyridine-2-sulfonyl)azepan-4-ylcarbamoyl]-2-phenyl-ethyl)amide	-	Homo sapiens
0.0000022	-	azepanone	-	Homo sapiens
0.000005	-	quinoline-2-carboxylic acid ((S)-1-[3-oxo-1-(pyridine-2-sulfonyl)azepan-4-ylcarbamoyl]-3-methyl-butyl)amide	-	Homo sapiens
0.0000082	-	quinoline-8-carboxylic acid ((S)-1-[3-oxo-1-(pyridine-2-sulfonyl)azepan-4-ylcarbamoyl]-3-methyl-butyl)amide	-	Homo sapiens

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Release 2023.1 (January 2023)