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Literature summary for 3.4.22.15 extracted from
- Purification and tissue distribution of rat cathepsin L (1986), J. Biochem., 100, 35-42.
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 25000 | - |
1 * 25000 + 1 * 5000, the enzyme consists of a single chain form of 30000 Da and of a two-chain form, SDS-PAGE in presence of 2-mercaptoethanol | Rattus norvegicus |
| 30000 | - |
1 * 30000, the enzyme consists of a single chain form of 30000 Da and of a two-chain form, SDS-PAGE in presence of 2-mercaptoethanol | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| gastrointestinal tract | - |
Rattus norvegicus | - |
| kidney | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
| lung | - |
Rattus norvegicus | - |
| lymphocyte | - |
Rattus norvegicus | - |
| macrophage | - |
Rattus norvegicus | - |
| additional information | the concentration of cathepsin L is highest in the kidney, where it is more than 3 times higher than in the liver, spleen, lungs and brain. Nervous tissues, especially the cerebellar cortex, also contains fairly high concentrations of cathepsin L, but the heart, skeletal muscle, and gastrointestinal tract contain low concentrations, as do peripheral blood cells. The enzyme content of the macrophages is 20% of that of cathepsin B. The concentration of cathepsin L in lymphocytes, neutrophils, and erythrocytes is 10%, 20% and less than 0.2% respectively, of those in resident macrophages | Rattus norvegicus | - |
| muscle | - |
Rattus norvegicus | - |
| neutrophil | - |
Rattus norvegicus | - |
| spleen | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 26.2 | - |
- |
Rattus norvegicus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, stable for a few weeks | Rattus norvegicus |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 1 * 25000 + 1 * 5000, the enzyme consists of a single chain form of 30000 Da and of a two-chain form, SDS-PAGE in presence of 2-mercaptoethanol | Rattus norvegicus |
| monomer | 1 * 30000, the enzyme consists of a single chain form of 30000 Da and of a two-chain form, SDS-PAGE in presence of 2-mercaptoethanol | Rattus norvegicus |
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