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Literature summary for 3.4.21.B43 extracted from
- KLK12 is a novel serine protease and a new member of the human kallikrein gene family-differential expression in breast cancer (2000), Genomics, 69, 331-341.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene KLK12, formerly KLK5, DNA sequence determination and analysis, chromosome mapping to 19q13.3-13.4, splice variants identification, genomic organization | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | hormonal reglation of enzyme expression, overview | ? | - |
? |  |
| polypeptide + H2O | Homo sapiens | involved in posttranslational processing of polypeptide precursors | peptides | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9UKR0 | gene KLK12 | - |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| proteolytic cleavage of polypeptides | enzyme is a serine protease | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | low content | Homo sapiens | - |
| breast | low content | Homo sapiens | - |
| breast | gene expression of the enzyme is down-regulated in breast cancer | Homo sapiens | - |
| colon | - |
Homo sapiens | - |
| lung | - |
Homo sapiens | - |
| additional information | no enzyme in heart, adrenal gland, spleen, placenta, skeletal muscle, testis, cerebellum, liver, spinal cord, kidney, and bone marrow | Homo sapiens | - |
| additional information | no enzyme in fetal liver and brain | Homo sapiens | - |
| prostate | - |
Homo sapiens | - |
| salivary gland | highest content | Homo sapiens | - |
| small intestine | very low content | Homo sapiens | - |
| stomach | - |
Homo sapiens | - |
| thymus | - |
Homo sapiens | - |
| thyroid gland | - |
Homo sapiens | - |
| trachea | - |
Homo sapiens | - |
| uterus | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | hormonal reglation of enzyme expression, overview | Homo sapiens | ? | - |
? | |
| polypeptide + H2O | - |
Homo sapiens | peptides | - |
? | |
| polypeptide + H2O | involved in posttranslational processing of polypeptide precursors | Homo sapiens | peptides | - |
? | |
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