Literature summary for 3.4.21.B12 extracted from

Vickers, A.; Vertosick, E.A.; Sjoberg, D.D.; Roobol, M.J.; Hamdy, F.; Neal, D.; Bjartell, A.; Hugosson, J.; Donovan, J.L.; Villers, A.; Zappala, S.; Lilja, H.
Properties of the 4-kallikrein panel outside the diagnostic gray zone meta-analysis of patients with positive digital rectal examination or prostate specific antigen 10 ng/ml and above (2017), J. Urol., 197, 607-613 .

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Application

Application	Comment	Organism
diagnostics	four-kallikrein panel is a prostate screening test. An important proportion number of men presenting for biopsy falls outside the diagnostic grey zone, having a positive digital rectal exam or prostate-specific antigen 10-25 ng/ml. The four kallikrein panel has good discrimination in these men, and use of the panel reduces biopsy rates in this group of men by over 20%. The use of the panel in men with positive digital rectal exam or prostate-specific antigen 10-25 is justified	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9Y5K2	-	-

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Release 2023.1 (January 2023)