Literature summary for 3.4.21.94 extracted from

Espinosa, V.P.; Liu, Y.; Ferrini, M.; Anghel, A.; Nie, Y.; Tripathi, P.V.; Porche, R.; Jansen, E.; Stuart, R.C.; Nillni, E.A.; Lutfy, K.; Friedman, T.C.
Differential regulation of prohormone convertase 1/3, prohormone convertase 2 and phosphorylated cyclic-AMP-response element binding protein by short-term and long-term morphine treatment: implications for understanding the "switch" to opiate addiction (2008), Neuroscience, 156, 788-799.

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Application

Application	Comment	Organism
molecular biology	the regulation of the prohormone processing system by morphine may lead to alterations in the levels of multiple bioactive hormones and may be a compensatory mechanism whereby the organism tries to restore its homeostatic hormonal milieu. The down-regulation of PC1/3, PC2 and P-CREB by short-term morphine and up-regulation by long-term morphine treatment may be a signal mediating the switch from drug use to drug abuse	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hypothalamus	the effects of short-term (24 h) and long-term (7-day) morphine treatment on the expression of hypothalamic PC1/3 and PC2 and levels of phosphorylated cyclic-AMP-response element binding protein are studied. While short-term morphine exposure down-regulates, long-term morphine exposure up-regulates cyclic-AMP-response element binding protein, PC1/3 and PC2 protein levels in the rat hypothalamus as determined by Western blot analysis	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
PC2	-	Rattus norvegicus

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Release 2023.1 (January 2023)