Literature summary for 3.4.21.94 extracted from

Wideman, R.D.; Covey, S.D.; Webb, G.C.; Drucker, D.J.; Kieffer, T.J.
A switch from prohormone convertase (PC)-2 to PC1/3 expression in transplanted alpha-cells is accompanied by differential processing of proglucagon and improved glucose homeostasis in mice (2007), Diabetes, 56, 2744-2752.

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Application

Application	Comment	Organism
medicine	transplantation of PC2-expressing alpha-cells increases plasma glucagon levels and causes mild fasting hyperglycemia, impairs glucose tolerance, and alpha-cell hypoplasia. PC2-expressing alpha-cells neither prevent streptozotocin-induced hyperglycemia nor increased beta-cell proliferation in the context of type 1 diabetes	Mus musculus

Cloned(Commentary)

Cloned (Comment)	Organism
transplantation of encapsulated PC2-expressing alpha TC-1 cells with PC1/3-expressing alpha TCdeltaPC2 cells in normal mice and low-dose streptozotocin-treated mice	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	CD-1 mice and C57B/6 mice	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	alpha TC1 cells express PC2, alpha TCdeltaPC2 cells do not express bioactive PC2	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
proglucagon + H2O	-	Mus musculus	glucagon	-	?

Synonyms

Synonyms	Comment	Organism
PC2	-	Mus musculus
prohormone convertase 2	-	Mus musculus

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Release 2023.1 (January 2023)