Literature summary for 3.4.21.94 extracted from

Marzban, L.; Rhodes, C.J.; Steiner, D.F.; Haataja, L.; Halban, P.A.; Verchere, C.B.
Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death (2006), Diabetes, 55, 2192-2201.

Search for more literature for 3.4.21.94

Application

Application	Comment	Organism
medicine	defects in processing, sorting, and/or secretion of (pro)IAPP associated with beta-cell dysfunction in type 2 diabetes and insulinomas may result in production and secretion of elevated levels of proIAPP and its NH(2)-terminally unprocessed form, leading to intracellular and/or fibril formation and beta-cell apoptosis. Restoration of intact IAPP processing may be a potential therapeutic approach to prevent or slow (pro)IAPP-induced beta-cell apoptosis and maintain beta-cell mass in type 2 diabetes	Mus musculus

Cloned(Commentary)

Cloned (Comment)	Organism
GH3 cells or INS-1 beta-cells cotransduced with proIAPP and PC2 by adenoviral expression	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	islets from mice lacking PC2 and with beta-cell expression of human proIAPP develop amyloid associated with beta-cell death during 2-week culture. Rescue of PC2 expression by ex vivo transduction with Ad-PC2 restores NH(2)-terminal processing to mature IAPP and decreases both the extent of amyloid formation and the number of TUNEL-positive cells, and enhances cell survival	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
proIAPP + H2O	enhanced NH(2)-terminal processing of proIAPP by adenoviral expression of PC2, reducing (pro)IAPP-induced cell death in GH3 cells. Overexpression of PC2 in INS-1 beta-cells also enhances NH(2)-terminal processing of proIAPP	Mus musculus	mature IAPP	-	?

Synonyms

Synonyms	Comment	Organism
PC2	-	Mus musculus
prohormone convertase 2	-	Mus musculus

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Release 2023.1 (January 2023)