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Literature summary for 3.4.21.94 extracted from

  • Sanchez, V.C.; Goldstein, J.; Stuart, R.C.; Hovanesian, V.; Huo, L.; Munzberg, H.; Friedman, T.C.; Bjorbaek, C.; Nillni, E.A.
    Regulation of hypothalamic prohormone convertases 1 and 2 and effects on processing of prothyrotropin-releasing hormone (2004), J. Clin. Invest., 114, 357-369.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
additional information leptin stimulates the PC1 expression via STAT3 acting on the PC2 promoter Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
expression of PC2 in human 293T cells, leptin has a stimulatory effect on the PC2 promoter, which is enhanced by co-expression of STAT3, overview Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information starvation reduces the serum levels of leptin which decreases PC1 expression, the effect can be reversed by administration of exogenous leptin Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
prothyrotropin-releasing hormone + H2O Rattus norvegicus processing and activation of the inactive prohormone is required for regulation of energy balance via leptin, enzyme regulation, overview thyrotropin-releasing hormone + pro-peptide of thyrotropin-releasing hormone
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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 male sprague-dawley rats
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Source Tissue

Source Tissue Comment Organism Textmining
hypothalamus
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 Rattus norvegicus
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neuron hypothalamic Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
prothyrotropin-releasing hormone + H2O processing and activation of the inactive prohormone is required for regulation of energy balance via leptin, enzyme regulation, overview Rattus norvegicus thyrotropin-releasing hormone + pro-peptide of thyrotropin-releasing hormone
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 ?
prothyrotropin-releasing hormone + H2O processing of the prohormone Rattus norvegicus thyrotropin-releasing hormone + pro-peptide of thyrotropin-releasing hormone
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 ?

Synonyms

Synonyms Comment Organism
PC2
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 Rattus norvegicus
prohormone convertase 2
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 Rattus norvegicus