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Literature summary for 3.4.21.94 extracted from

  • Marzban, L.; Trigo-Gonzalez, G.; Zhu, X.; Rhodes, C.J.; Halban, P.A.; Steiner, D.F.; Verchere, C.B.
    Role of beta-cell prohormone convertase (PC)1/3 in processing of pro-islet amyloid polypeptide (2004), Diabetes, 53, 141-148.
    View publication on PubMed
Search for more literature for 3.4.21.94

Cloned(Commentary)

Cloned (Comment) Organism
co-expression of PC2 and rat pro-islet amyloid polypeptide, proIAPP, in GH3 cells lacking the enzyme, does not lead to complete cleavage of recombinant proIAPP, but to cleavage of the C-terminal site of proIAPP Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-islet amyloid polypeptide + H2O Mus musculus precursor of IAPP or amylin, the major component of islet amyloid, cleavage at the N-terminus, but not the C-terminus, which would also be required for activation, the complete activation is catalyzed by PC1, EC 3.4.21.93 islet amyloid polypeptide processing intermediate + N-terminal pro-peptide
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
B-cell
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro-islet amyloid polypeptide + H2O precursor of IAPP or amylin, the major component of islet amyloid, cleavage at the N-terminus, but not the C-terminus, which would also be required for activation, the complete activation is catalyzed by PC1, EC 3.4.21.93 Mus musculus islet amyloid polypeptide processing intermediate + N-terminal pro-peptide
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 ?

Synonyms

Synonyms Comment Organism
PC2
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 Mus musculus
prohormone convertase 2
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 Mus musculus