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Literature summary for 3.4.21.94 extracted from

  • Apletalina, E.V.; Muller, L.; Lindberg, I.
    Mutations in the catalytic domain of prohormone convertase 2 result in decreased binding to 7B2 and loss of inhibition with 7B2 C-terminal peptide (2000), J. Biol. Chem., 275, 14667-14677.
    View publication on PubMed
Search for more literature for 3.4.21.94

Activating Compound

Activating Compound Comment Organism Structure
protein 7B2 pro-PC2 requires interaction with this neuroendocrine-specific protein for its maturation and activation Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
cDNA construction of PC2 mutants, expressed in CHO/21-kDA 7B2 cells Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
7B2 C-terminal peptide
-
 Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
64000
-
 bioactive PC2, Western blot analysis Mus musculus
66000
-
 Western blot analysis Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
proenkephalin + H2O Mus musculus
-
 opioid-active enkephalin + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 mouse, AtT-20 cells
-

Purification (Commentary)

Purification (Comment) Organism
wild-type, partially Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
proenkephalin + H2O
-
 Mus musculus opioid-active enkephalin + ?
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5
-
-
 Mus musculus

pH Range

pH Minimum pH Maximum Comment Organism
4 6
-
 Mus musculus