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Literature summary for 3.4.21.94 extracted from

  • Day, R.; Lazure, C.; Basak, A.; Boudreault, A.; Limperis, P.; Dong, W.; Lindberg, I.
    Prodynorphin processing by proprotein convertase 2. Cleavage at single basic residues and enhanced processing in the presence of carboxypeptidase activity (1998), J. Biol. Chem., 273, 829-836.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
overexpressed in Chinese hamster ovary cells supertransfected with rat cDNA 7B2 Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.032
-
pGlu-Arg-Thr-Lys-Arg-methylcoumarin amide pH 5.0, 37°C Mus musculus
0.077
-
leumorphin pH 5.0, 37°C Mus musculus
0.079
-
dynorphin A 1-17 pH 5.0, 37°C Mus musculus
0.1
-
dynorphin AB 1-32 pH 5.0, 37°C Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
mouse
-
Rattus norvegicus
-
rat, Sprague-Dawley
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme Mus musculus

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.015
-
-
Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Cbz-Arg-Ser-Lys-Arg-aminomethylcoumarin + H2O
-
Mus musculus ?
-
?
dynorphin A 1-17 + H2O
-
Mus musculus ?
-
?
dynorphin AB 1-32 + H2O
-
Mus musculus ?
-
?
leumorphin + H2O
-
Mus musculus ?
-
?
prodynorphin + H2O
-
Mus musculus dynorphin A 1-17 + dynorphin B 1-13 + alpha-neo-endorphin + C-peptide + dynorphin A 1-8 + ?
-
?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
42.5
-
no significant loss of PC2 activity is observed below 42.5°C Mus musculus