Cloned (Comment) | Organism |
---|---|
overexpressed in Chinese hamster ovary cells supertransfected with rat cDNA | Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.11 | - |
CBZ-Arg-Ser-Lys-Arg-4-methylcoumarin 7-amide | pH 5.0, 37°C | Mus musculus | |
0.14 | - |
Ac-Lys-Ser-Lys-Arg-4-methylcoumarin 7-amide | pH 5.0, 37°C | Mus musculus | |
0.26 | - |
Ac-Arg-Pro-Lys-Arg-4-methylcoumarin 7-amide | pH 5.0, 37°C | Mus musculus | |
0.27 | - |
Ac-Arg-Phe-Ala-Arg-4-methylcoumarin 7-amide | pH 5.0, 37°C | Mus musculus | |
0.33 | - |
Ac-Orn-Ser-Lys-Arg-4-methylcoumarin 7-amide | pH 5.0, 37°C | Mus musculus | |
0.44 | - |
Boc-Gly-Lys-Arg-4-methylcoumarin 7-amide | pH 5.0, 37°C | Mus musculus | |
0.51 | - |
Boc-Gly-Arg-Arg-4-methylcoumarin 7-amide | pH 5.0, 37°C | Mus musculus | |
1.3 | - |
Boc-Val-Pro-Arg-4-methylcoumarin 7-amide | pH 5.0, 37°C | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
proenkephalin + H2O | Mus musculus | cleaves prohormones and proneuropeptides from inactive large precursors to generate activre peptide for extracellular release | opioid-active enkephalin + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
mouse | - |
Purification (Comment) | Organism |
---|---|
recombinant enzyme | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-aminobenzoyl-LPSDEEGESYKEVPEMEKRYGGFMQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O | - |
Mus musculus | 2-aminobenzoyl-LPSDEEGESYKEVPEMEKR + YGGFMQ-N-(2,4-dinitrophenyl)ethylenediamine | - |
? | |
2-aminobenzoyl-Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-Gly-Arg-Pro-Glu-N-(2,4-dinitrophenyl)ethylenediamine + H2O | - |
Mus musculus | ? | - |
? | |
2-aminobenzoyl-Val-Pro-Arg-Met-Glu-Lys-Arg-Tyr-Gly-Gly-Phe-Met-Gln-N-(2,4-dinitrophenyl)ethylenediamine + H2O | - |
Mus musculus | ? | - |
? | |
Ac-Arg-Phe-Ala-Arg-4-methylcoumarin 7-amide + H2O | - |
Mus musculus | Ac-Arg-Phe-Ala-Arg + 7-amino-4-methylcoumarin | - |
? | |
Ac-Arg-Pro-Lys-Arg-4-methylcoumarin 7-amide + H2O | - |
Mus musculus | Ac-Arg-Pro-Lys-Arg + 7-amino-4-methylcoumarin | - |
? | |
Ac-Lys-Ser-Lys-Arg-4-methylcoumarin 7-amide + H2O | - |
Mus musculus | Ac-Lys-Ser-Lys-Arg + 7-amino-4-methylcoumarin | - |
? | |
Ac-Orn-Ser-Lys-Arg-4-methylcoumarin 7-amide + H2O | - |
Mus musculus | Ac-Orn-Ser-Lys-Arg + 7-amino-4-methylcoumarin | - |
? | |
Boc-Gly-Arg-Arg-4-methylcoumarin 7-amide + H2O | - |
Mus musculus | Boc-Gly-Arg-Arg + 7-amino-4-methylcoumarin | - |
? | |
Boc-Gly-Lys-Arg-4-methylcoumarin 7-amide + H2O | - |
Mus musculus | Boc-Gly-Lys-Arg + 7-amino-4-methylcoumarin | - |
? | |
Boc-Val-Pro-Arg-4-methylcoumarin 7-amide + H2O | - |
Mus musculus | Boc-Val-Pro-Arg + 7-amino-4-methylcoumarin | - |
? | |
CBZ-Arg-Ser-Lys-Arg-4-methylcoumarin 7-amide + H2O | - |
Mus musculus | CBZ-Arg-Ser-Lys-Arg + 7-amino-4-methylcoumarin | - |
? | |
additional information | prefers Arg at positions P4 and P5 in peptide B IQ substrates, Boc-Val-Leu-Lys-4-methylcoumarin 7-amide is no substrate | Mus musculus | ? | - |
? | |
pGlu-Arg-Thr-Lys-Arg-4-methylcoumarin 7-amide + H2O | - |
Mus musculus | pGlu-Arg-Thr-Lys-Arg + 7-amino-4-methylcoumarin | - |
? | |
proenkephalin + H2O | - |
Mus musculus | opioid-active enkephalin + ? | - |
? | |
proenkephalin + H2O | cleaves prohormones and proneuropeptides from inactive large precursors to generate activre peptide for extracellular release | Mus musculus | opioid-active enkephalin + ? | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.6 | - |
Ac-Arg-Phe-Ala-Arg-4-methylcoumarin 7-amide | pH 5.0, 37°C | Mus musculus | |
1.2 | - |
Boc-Gly-Lys-Arg-4-methylcoumarin 7-amide | pH 5.0, 37°C | Mus musculus | |
1.8 | - |
Boc-Gly-Arg-Arg-4-methylcoumarin 7-amide | pH 5.0, 37°C | Mus musculus | |
34.2 | - |
pGlu-Arg-Thr-Lys-Arg-4-methylcoumarin 7-amide | pH 5.0, 37°C | Mus musculus | |
34.2 | - |
CBZ-Arg-Ser-Lys-Arg-4-methylcoumarin 7-amide | pH 5.0, 37°C | Mus musculus | |
39.6 | - |
Ac-Orn-Ser-Lys-Arg-4-methylcoumarin 7-amide | pH 5.0, 37°C | Mus musculus | |
43.8 | - |
Ac-Lys-Ser-Lys-Arg-4-methylcoumarin 7-amide | pH 5.0, 37°C | Mus musculus | |
99 | - |
Ac-Arg-Pro-Lys-Arg-4-methylcoumarin 7-amide | pH 5.0, 37°C | Mus musculus |