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Literature summary for 3.4.21.93 extracted from

  • Kilimnik, G.; Kim, A.; Steiner, D.; Friedman, T.; Hara, M.
    Intraislet production of GLP-1 by activation of prohormone convertase 1/3 in pancreatic alpha-cells in mouse models of beta-cell regeneration (2010), Islets, 2, 149-155.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine significant activation of PC1/3 in the alpha-cells of pancreatic islet is observed in mouse models of insulin resistance such as pregnant, obese, diabetic and prediabetic NOD mice. Data suggest a role of alpha-cells for beta-cell proliferation and further for the endocrine cell network within an islet Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
pancreatic islet alpha-cells in the islet of Langerhans express both prohormone convertase 2 and 1/3, which results in the processing of the proglucagon precursor into glucagon-like peptide 1, thereby leading to local production of this beta-cell growth factor. alpha-Cells in the adult basically only express PC2, but significant activation of PC1/3 is also observed in mouse models of insulin resistance such as pregnant, obese, diabetic and prediabetic NOD mice Mus musculus
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