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Literature summary for 3.4.21.93 extracted from

  • Espinosa, V.P.; Liu, Y.; Ferrini, M.; Anghel, A.; Nie, Y.; Tripathi, P.V.; Porche, R.; Jansen, E.; Stuart, R.C.; Nillni, E.A.; Lutfy, K.; Friedman, T.C.
    Differential regulation of prohormone convertase 1/3, prohormone convertase 2 and phosphorylated cyclic-AMP-response element binding protein by short-term and long-term morphine treatment: implications for understanding the "switch" to opiate addiction (2008), Neuroscience, 156, 788-799.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
morphine long-term morphine exposure (7 days) upregulates prohormone convertase 1/3 protein levels in the rat hypothalamus. The cyclic-AMP response element in the promoter of prohormone convertase 1/3 is required for morphine-induced regulation of prohormone convertase 1/3 Rattus norvegicus
Naltrexone stimulates prohormone convertase 1/3 promoter activity Homo sapiens

Application

Application Comment Organism
medicine downregulation of prohormone convertase 1/3 by short-term morphine and upregulation by long-term morphine treatment may be a signal mediating the switch from drug use to drug abuse Homo sapiens
medicine downregulation of prohormone convertase 1/3 by short-term morphine and upregulation by long-term morphine treatment may be a signal mediating the switch from drug use to drug abuse Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
transfection of pituitary GH3 cells with promoter for human prohormone convertase 1/3 or with the prohormone convertase 1/3-minusCRE1/2 promoter construct Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
morphine human prohormone convertase 1/3 promoter activity is 73.1% in GH3-mu-opioid receptor cells receiving morphine compared with cells receiving media, and this reduction is reversed by naltrexone. In cells transfected with the prohormone convertase 1/3-minusCRE1/2 promoter construct, morphine does not reduce prohormone convertase 1/3-promoter activity. In wild-type GH3 cells (without the mu-opioid receptor), human prohormone convertase 1/3 promoter does not respond to morphine treatment. Regulation of prohormone convertase 1/3 promoter activity by morphine is mediated through the mu-opioid receptor Homo sapiens
morphine short-term morphine (24 h) exposure downregulates prohormone convertase 1/3 protein levels in the rat hypothalamus. The cyclic-AMP response element in the promoter of prohormone convertase 1/3 is required for morphine-induced regulation of prohormone convertase 1/3 Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
66000
-
 Western blot analysis Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
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 adult male Sprague-Dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
hypothalamus increase in prohormone convertase 1/3 is most abundant in the ventral region of the posterior region of the hypothalamic nucleus and in the paraventricular hypothalamic medial area Rattus norvegicus
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neuron in the dorso-medial nucleus, significant increase in the number of prohormone convertase 1/3-positive neurons after long-term morphine exposure Rattus norvegicus
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Synonyms

Synonyms Comment Organism
PC1/3
-
 Homo sapiens
PC1/3
-
 Rattus norvegicus
prohormone convertase 1/3
-
 Homo sapiens
prohormone convertase 1/3
-
 Rattus norvegicus