Activating Compound | Comment | Organism | Structure |
---|---|---|---|
pioglitazone | oral medication used in the treatment of type 2 diabetes, which decreases Pdcd4 levels, activates Akt, increases CgA and Sg II secretion and augments proprotein convertase 1/3 protein in Bon-1 cells. 7fold increase in proprotein convertase 1/3 mRNA in shPdcd4-transfected cells | Homo sapiens |
Application | Comment | Organism |
---|---|---|
drug development | repression of proprotein convertase 1/3 by Pdcd4 may represent a novel mechanism for the function of Pdcd4 as a tumour suppressor | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | proprotein convertase 1/3 expression is reduced in Bon-1 cells overexpressing Pdcd4 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
BON-1 cell | neuroendocrine cell line, which shows dramatic increase in proprotein convertase 1/3 protein expression after suppression of Pdcd4 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | enhanced proprotein convertase 1/3 levels, leading to improved processing of proinsulin and proglucagon, may contribute to the benefits of pioglitazone therapy | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PC1 | - |
Homo sapiens |
proprotein convertase 1/3 | - |
Homo sapiens |