Literature summary for 3.4.21.93 extracted from

Wideman, R.D.; Covey, S.D.; Webb, G.C.; Drucker, D.J.; Kieffer, T.J.
A switch from prohormone convertase (PC)-2 to PC1/3 expression in transplanted alpha-cells is accompanied by differential processing of proglucagon and improved glucose homeostasis in mice (2007), Diabetes, 56, 2744-2752.

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Application

Application	Comment	Organism
medicine	transplantation of PC1/3-expressing alpha-cells prevents streptozotocin-induced hyperglycemia by preserving beta-cell area and islet morphology, possibly via stimulating beta-cell replication. Expression of PC1/3 rather than PC2 in alpha-cells induces glucagon-like peptide 1 and glucagon-like peptide 2 production and converts the alpha-cell from a hyperglycemia-promoting cell to one that lowers blood glucose levels. Alteration of proglucagon processing in the alpha-cell may be therapeutically useful in the context of type 1 diabetes	Mus musculus

Cloned(Commentary)

Cloned (Comment)	Organism
transplantation of encapsulated PC2-expressing alpha TC-1 cells with PC1/3-expressing alpha TCdeltaPC2 cells in normal mice and low-dose streptozotocin-treated mice	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	CD-1 mice and C57B/6 mice	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	alphaTCdeltaPC2 cells express abundant PC1/3, whereas alphaTC-1 cells express little or no PC1/3	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
proglucagon + H2O	-	Mus musculus	glucagon-like peptide 1	-	?

Synonyms

Synonyms	Comment	Organism
PC1/3	-	Mus musculus
prohormone convertase 1/3	-	Mus musculus

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Release 2023.1 (January 2023)