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Literature summary for 3.4.21.93 extracted from
- Cellular colocalization and coregulation between hypothalamic pro-TRH and prohormone convertases in hypothyroidism (2007), Am. J. Physiol. Endocrinol. Metab., 292, E175-E186.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 6-n-propyl-2-thiouracil | produces hypothyroidism and induces a significant increase in the expression of PC1/3 in the paraventricular nucleus and lateral hypothalamus, but not ventromedial nucleus. Regulates colocalization of PC1/3 or PC2 in pro-thyrotropin-releasing hormone in the paraventricular nucleus, but not in lateral hypothalamus and ventromedial nucleus | Rattus norvegicus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
adult male Sprague-Dawley rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | paraventricular nucleus, lateral hypothalamus and ventromedial nucleus | Rattus norvegicus | - |
| hypothalamus | - |
Rattus norvegicus | - |
| neuron | discrete expression of PC1/3 in the paraventricular nucleus, lateral hypothalamus and ventromedial nucleus of euthyroid animals | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| prothyrotropin-releasing hormone + H2O | - |
Rattus norvegicus | thyrotropin-releasing hormone + pro-peptide of thyrotropin-releasing hormone | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PC1/3 | - |
Rattus norvegicus |
| prohormone convertase | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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