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Literature summary for 3.4.21.93 extracted from

  • Lee, S.N.; Prodhomme, E.; Lindberg, I.
    Prohormone convertase 1 (PC1) processing and sorting: effect of PC1 propeptide and proSAAS (2004), J. Endocrinol., 182, 353-364.
    View publication on PubMed
Search for more literature for 3.4.21.93

Cloned(Commentary)

Cloned (Comment) Organism
expression of chimeric PC1-propeptide/SAAS CT peptide constructs in AtT20 cells and in HEK293 cells Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information generation of chimeric PC1-propeptide/SAAS CT peptide constructs, effects on C-terminal PC1 processing are limited to the construct containing the PC1 propeptide alone when expressed in AtT20 cells, while both the PC1 propeptide and the SAAS CT propeptide are inhibitory on C-terminal PC1 zymogen processing when expressed in HEK293 cells, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
PC1 propeptide inhibits the mature PC1 Mus musculus
proSAAS CT peptide endogenous inhibitor, inhibits the C-terminal PC1 processing Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
87000
-
 x * 87000, PC1 zymogen, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus the enzyme is involved in the regulated secretory pathway in neuroendocrine cells, the enzyme activity is regulated by the PC1-propeptide and by proSAAS CT peptide ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein the catalytic domain of PC1 contains two N-glycosylation sites, the C-terminal domain contains one N-glycosylation site Mus musculus
proteolytic modification PC1 zymogen is activated by proteolytic cleavage of the signal and the propeptide and is processed at the C-terminal domain, which is regulated by the separate PC1 propeptide and the SAAS CT propeptide, overview Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
AtT-20 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is involved in the regulated secretory pathway in neuroendocrine cells, the enzyme activity is regulated by the PC1-propeptide and by proSAAS CT peptide Mus musculus ?
-
 ?

Subunits

Subunits Comment Organism
? x * 87000, PC1 zymogen, SDS-PAGE Mus musculus
More PC1 domain structure, overview Mus musculus

Synonyms

Synonyms Comment Organism
PC1
-
 Mus musculus
prohormone convertase 1
-
 Mus musculus