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Literature summary for 3.4.21.93 extracted from

  • Posner, S.F.; Vaslet, C.A.; Jurofcik, M.; Lee, A.; Seidah, N.G.; Nillni, E.A.
    Stepwise posttranslational processing of pro-growth hormone-releasing hormone (proGHRH) polypeptide by furin and PC1 (2004), Endocrine, 23, 199-213.
    View publication on PubMed
Search for more literature for 3.4.21.93

Cloned(Commentary)

Cloned (Comment) Organism
expression of PC1 in GH3 cells, co-expression with proGHRH or preproGHRH, GH3 cells lack endogenous PC1 but contain PC2, EC 3.4.21.94, another prohormone processing enzyme Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-growth hormone-releasing hormone + H2O Mus musculus posttranslational processing mechanism, PC1 is the primary enzyme involved in the processing, overview growth hormone-releasing hormone + GHRH-RP + pro-peptide of growth hormone-releasing hormone
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
AtT-20 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro-growth hormone-releasing hormone + H2O posttranslational processing mechanism, PC1 is the primary enzyme involved in the processing, overview Mus musculus growth hormone-releasing hormone + GHRH-RP + pro-peptide of growth hormone-releasing hormone
-
 ?
pro-growth hormone-releasing hormone + H2O proGHRH, processing Mus musculus growth hormone-releasing hormone + GHRH-RP + pro-peptide of growth hormone-releasing hormone products are the pro-peptide of 1.7 kDa, the mature GHRH of 5.2 kDa, and GHRH-RP of 3.6 kDa ?

Synonyms

Synonyms Comment Organism
PC1
-
 Mus musculus