Literature summary for 3.4.21.73 extracted from

Wu, F.; Catano, M.; Echeverry, R.; Torre, E.; Haile, W.B.; An, J.; Chen, C.; Cheng, L.; Nicholson, A.; Tong, F.C.; Park, J.; Yepes, M.
Urokinase-type plasminogen activator promotes dendritic spine recovery and improves neurological outcome following ischemic stroke (2014), J. Neurosci., 34, 14219-14232.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-
Mus musculus E16-E18	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
neuron	cerebral cortical, release of enzyme during the recovery phase from ischemic stroke in vivo or hypoxia in vitro	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
uPA	-	Mus musculus
Urokinase-type plasminogen activator	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	genetic deficiency of enzyme or urokinase plasminogen activator receptor abrogates functional recovery after acute ischemic stroke	Mus musculus
physiological function	urokinase-type plasminogen activator is a serine proteinase that plays a central role in tissue remodeling via binding to the urokinase plasminogen activator receptor and promotes dendritic spine recovery and improves neurological outcome following ischemic stroke. The enzyme does not have an effect on ischemia- or hypoxia-induced neuronal death. The excitotoxic injury induces the clustering of enzyme receptor in dendritic varicosities, and the binding of the enzyme and its receptor promotes the reorganization of the actin cytoskeleton and re-emergence of dendritic filopodia from enzyme receptor-enriched varicosities mediated by Rac-regulated profilin expression and cofilin phosphorylation	Mus musculus

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Release 2023.1 (January 2023)