Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-([6-[(3'-carbamimidoylbiphenyl-3-yl)oxy]-3,5-difluoro-4-methylpyridin-2-yl]oxy)-4-(dimethylamino)benzoic acid | - |
Homo sapiens | |
2-[(6-[[3'-(aminomethyl)biphenyl-3-yl]oxy]-3,5-difluoropyridin-2-yl)oxy]-4-methylbenzoic acid | - |
Homo sapiens | |
2-[(6-[[5-amino-3'-(aminomethyl)biphenyl-3-yl]oxy]-3,5-difluoropyridin-2-yl)oxy]-4-methylbenzoic acid | - |
Homo sapiens | |
4'-(6-cyano-2-naphthamido)biphenyl-3-carboxylic acid | slight inhibition | Homo sapiens | |
4'-(6-methoxynaphthalene-2-sulfonamido)biphenyl-3-carboxamide | slight inhibition | Homo sapiens | |
4-(2-aminoethoxy)-N-[3-chloro-2-ethoxy-5-(piperidin-1-yl)phenyl]-3,5-dimethylbenzamide | - |
Homo sapiens | |
4-[(E)-(5-oxo-2-phenyl-1,3-oxazol-4(5H)-ylidene)methyl]benzenecarboximidamide | - |
Homo sapiens | |
6-(phenylcarbamoyl)-2-naphthoic acid | slight inhibition | Homo sapiens | |
6-amino-N-phenyl-2-naphthamide | slight inhibition | Homo sapiens | |
6-bromo-N-phenyl-2-naphthamide | slight inhibition | Homo sapiens | |
6-carbamimidoyl-N-(3,5-dimethoxyphenyl)-2-naphthamide | - |
Homo sapiens | |
6-carbamimidoyl-N-phenyl-2-naphthamide | - |
Homo sapiens | |
6-cyano-N-(3'-methoxybiphenyl-4-yl)-2-naphthamide | - |
Homo sapiens | |
6-cyano-N-(3,5-dimethoxyphenyl)-2-naphthamide | - |
Homo sapiens | |
6-cyano-N-phenylnaphthalene-2-carboxamide | slight inhibition | Homo sapiens | |
6-methoxy-N-(3'-(trifluoromethyl)biphenyl-4-yl)-2-naphthamide | - |
Homo sapiens | |
6-methoxy-N-(3'-(trifluoromethyl)biphenyl-4-yl)naphthalene-2-sulfonamide | - |
Homo sapiens | |
6-methoxy-N-(3'-methoxybiphenyl-4-yl)-2-naphthamide | - |
Homo sapiens | |
6-methoxy-N-(3'-methoxybiphenyl-4-yl)naphthalene-2-sulfonamide | - |
Homo sapiens | |
6-methoxy-N-(3'-nitrobiphenyl-4-yl)-2-naphthamide | - |
Homo sapiens | |
6-methoxy-N-(3'-nitrobiphenyl-4-yl)naphthalene-2-sulfonamide | - |
Homo sapiens | |
6-methoxy-N-(4'-methoxybiphenyl-4-yl)-2-naphthamide | - |
Homo sapiens | |
6-methoxy-N-(4'-methoxybiphenyl-4-yl)naphthalene-2-sulfonamide | - |
Homo sapiens | |
6-methoxy-N-phenyl-2-naphthamide | slight inhibition | Homo sapiens | |
bis[(phenylamino)acetyl] [2-(4-carbamimidamidophenyl)-1-[(methoxycarbonyl)amino]ethyl]phosphonate | - |
Homo sapiens | |
diphenyl [2-(4-carbamimidamidophenyl)-1-[(methoxycarbonyl)amino]ethyl]phosphonate | - |
Homo sapiens | |
ethyl 4-(3-carbamimidoyl-N-[[2,4,6-tri(propan-2-yl)phenyl]sulfonyl]-L-phenylalanyl)piperazine-1-carboxylate | - |
Homo sapiens | |
methyl 4'-(2-naphthamido)biphenyl-3-carboxylate | - |
Homo sapiens | |
methyl 4'-(6-amino-2-naphthamido)biphenyl-3-carboxylate | - |
Homo sapiens | |
methyl 4'-(6-bromo-2-naphthamido)biphenyl-3-carboxylate | - |
Homo sapiens | |
methyl 4'-(6-carbamoyl-2-naphthamido)biphenyl-3-carboxylate | - |
Homo sapiens | |
methyl 4'-(6-chloro-2-naphthamido)biphenyl-3-carboxylate | - |
Homo sapiens | |
methyl 4'-(6-cyano-2-naphthamido)biphenyl-3-carboxylate | - |
Homo sapiens | |
methyl 4'-(6-methoxy-2-naphthamido)biphenyl-3-carboxylate | - |
Homo sapiens | |
methyl 4'-(6-methoxynaphthalene-2-sulfonamido)biphenyl-3-carboxylate | - |
Homo sapiens | |
methyl 4'-(6-methoxynaphthalene-2-sulfonamido)biphenyl-4-carboxylate | - |
Homo sapiens | |
methyl 4'-(naphthalene-2-sulfonamido)biphenyl-3-carboxylate | - |
Homo sapiens | |
methyl 4'-(naphthalene-2-sulfonamido)biphenyl-4-carboxylate | - |
Homo sapiens | |
methyl 6-(3'-(methoxycarbonyl)biphenyl-4-ylcarbamoyl)-2-naphthoate | - |
Homo sapiens | |
methyl 6-(phenylcarbamoyl)-2-naphthoate | slight inhibition | Homo sapiens | |
additional information | synthesis and evaluation of a series of naphthamide and naphthalene sulfonamides as enzyme inhibitors containing non-basic groups as substitute for amidine or guanidine groups, overview | Homo sapiens | |
N-(2,4'-dimethoxybiphenyl-4-yl)-6-methoxynaphthalene-2-sulfonamide | - |
Homo sapiens | |
N-(2,4-dimethoxybiphenyl-4-yl)-6-methoxy-2-naphthamide | slight inhibition | Homo sapiens | |
N-(3',4'-dimethoxybiphenyl-4-yl)-6-methoxy-2-naphthamide | - |
Homo sapiens | |
N-(3',4'-dimethoxybiphenyl-4-yl)-6-methoxynaphthalene-2-sulfonamide | - |
Homo sapiens | |
N-(3'-aminobiphenyl-4-yl)-6-methoxynaphthalene-2-sulfonamide | - |
Homo sapiens | |
N-(3'-chlorobiphenyl-4-yl)-6-methoxynaphthalene-2-sulfonamide | slight inhibition | Homo sapiens | |
N-(3'-fluorobiphenyl-4-yl)-6-methoxynaphthalene-2-sulfonamide | slight inhibition | Homo sapiens | |
N-(3'-methoxybiphenyl-4-yl)-2-naphthamide | - |
Homo sapiens | |
N-(3'-methoxybiphenyl-4-yl)naphthalene-2-sulfonamide | - |
Homo sapiens | |
N-(4-(aminomethyl)phenyl)-6-carbamimidoyl-2-naphthamide trifluoro acetate | - |
Homo sapiens | |
N-(benzylsulfonyl)-D-seryl-N-(4-carbamimidoylbenzyl)-L-alaninamide | - |
Homo sapiens | |
N-(biphenyl-4-yl)-6-methoxynaphthalene-2-sulfonamide | - |
Homo sapiens | |
N-phenyl-2-naphthamide | slight inhibition | Homo sapiens | |
N2-(2,4'-dimethoxybiphenyl-4-yl)naphthalene-2,6-dicarboxamide | - |
Homo sapiens | |
N2-(3'-(trifluoromethyl)biphenyl-4-yl)naphthalene-2,6-dicarboxamide | - |
Homo sapiens | |
N2-(3'-methoxybiphenyl-4-yl)naphthalene-2,6-dicarboxamide | - |
Homo sapiens | |
N2-(3,5-dimethoxyphenyl)naphthalene-2,6-dicarboxamide | - |
Homo sapiens | |
N2-(3-chlorobiphenyl-4-yl)naphthalene-2,6-dicarboxamide | - |
Homo sapiens | |
N2-(4-(aminomethyl)phenyl)naphthalene-2,6-dicarboxamide trifluoroacetate | - |
Homo sapiens | |
N2-phenylnaphthalene-2,6-dicarboxamide | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P00749 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-Ile-Pro-Arg-4-nitroanilide + H2O | - |
Homo sapiens | D-Ile-Pro-Arg + 4-nitroaniline | - |
? | |
plasmin + H2O | - |
Homo sapiens | ? | - |
? | |
pyro-Glu-Pro-Arg-4-nitroanilide + H2O | - |
Homo sapiens | pyro-Glu-Pro-Arg + 4-nitroaniline | - |
? | |
thrombin + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
uPA | - |
Homo sapiens |
Urokinase-type plasminogen activator | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.8 | - |
assay at | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000077 | - |
N-(benzylsulfonyl)-D-seryl-N-(4-carbamimidoylbenzyl)-L-alaninamide | pH 8.8, 37°C | Homo sapiens | |
0.00004 | - |
N-(4-(aminomethyl)phenyl)-6-carbamimidoyl-2-naphthamide trifluoro acetate | pH 8.8, 37°C | Homo sapiens | |
0.000139 | - |
6-carbamimidoyl-N-(3,5-dimethoxyphenyl)-2-naphthamide | pH 8.8, 37°C | Homo sapiens | |
0.00041 | - |
ethyl 4-(3-carbamimidoyl-N-[[2,4,6-tri(propan-2-yl)phenyl]sulfonyl]-L-phenylalanyl)piperazine-1-carboxylate | pH 8.8, 37°C | Homo sapiens | |
0.000631 | - |
6-carbamimidoyl-N-phenyl-2-naphthamide | pH 8.8, 37°C | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000031 | - |
pH 8.8, 37°C | Homo sapiens | diphenyl [2-(4-carbamimidamidophenyl)-1-[(methoxycarbonyl)amino]ethyl]phosphonate | |
0.0000034 | - |
pH 8.8, 37°C | Homo sapiens | bis[(phenylamino)acetyl] [2-(4-carbamimidamidophenyl)-1-[(methoxycarbonyl)amino]ethyl]phosphonate | |
0.000039 | - |
pH 8.8, 37°C | Homo sapiens | 2-[(6-[[5-amino-3'-(aminomethyl)biphenyl-3-yl]oxy]-3,5-difluoropyridin-2-yl)oxy]-4-methylbenzoic acid | |
0.000072 | - |
pH 8.8, 37°C | Homo sapiens | 4-(2-aminoethoxy)-N-[3-chloro-2-ethoxy-5-(piperidin-1-yl)phenyl]-3,5-dimethylbenzamide | |
0.000098 | - |
pH 8.8, 37°C | Homo sapiens | 2-([6-[(3'-carbamimidoylbiphenyl-3-yl)oxy]-3,5-difluoro-4-methylpyridin-2-yl]oxy)-4-(dimethylamino)benzoic acid | |
0.0002 | - |
pH 8.8, 37°C | Homo sapiens | 4-[(E)-(5-oxo-2-phenyl-1,3-oxazol-4(5H)-ylidene)methyl]benzenecarboximidamide | |
0.00024 | - |
pH 8.8, 37°C | Homo sapiens | 2-[(6-[[3'-(aminomethyl)biphenyl-3-yl]oxy]-3,5-difluoropyridin-2-yl)oxy]-4-methylbenzoic acid | |
0.0012 | - |
pH 8.8, 37°C | Homo sapiens | N-(4-(aminomethyl)phenyl)-6-carbamimidoyl-2-naphthamide trifluoro acetate | |
0.0021 | - |
pH 8.8, 37°C | Homo sapiens | 6-methoxy-N-(3'-(trifluoromethyl)biphenyl-4-yl)-2-naphthamide | |
0.0024 | - |
pH 8.8, 37°C | Homo sapiens | N2-(3'-(trifluoromethyl)biphenyl-4-yl)naphthalene-2,6-dicarboxamide | |
0.0026 | - |
pH 8.8, 37°C | Homo sapiens | 6-carbamimidoyl-N-(3,5-dimethoxyphenyl)-2-naphthamide | |
0.0026 | - |
pH 8.8, 37°C | Homo sapiens | 6-methoxy-N-(3'-nitrobiphenyl-4-yl)-2-naphthamide | |
0.0028 | - |
pH 8.8, 37°C | Homo sapiens | methyl 4'-(6-methoxynaphthalene-2-sulfonamido)biphenyl-3-carboxylate | |
0.0029 | - |
pH 8.8, 37°C | Homo sapiens | N2-(3'-methoxybiphenyl-4-yl)naphthalene-2,6-dicarboxamide | |
0.0036 | - |
pH 8.8, 37°C | Homo sapiens | methyl 4'-(6-carbamoyl-2-naphthamido)biphenyl-3-carboxylate | |
0.004 | - |
pH 8.8, 37°C | Homo sapiens | methyl 4'-(6-methoxy-2-naphthamido)biphenyl-3-carboxylate | |
0.004 | - |
pH 8.8, 37°C | Homo sapiens | 6-methoxy-N-(3'-methoxybiphenyl-4-yl)-2-naphthamide | |
0.0041 | - |
pH 8.8, 37°C | Homo sapiens | 6-methoxy-N-(3'-(trifluoromethyl)biphenyl-4-yl)naphthalene-2-sulfonamide | |
0.0064 | - |
pH 8.8, 37°C | Homo sapiens | N2-(2,4'-dimethoxybiphenyl-4-yl)naphthalene-2,6-dicarboxamide | |
0.0069 | - |
pH 8.8, 37°C | Homo sapiens | 6-methoxy-N-(3'-nitrobiphenyl-4-yl)naphthalene-2-sulfonamide | |
0.007 | - |
pH 8.8, 37°C | Homo sapiens | methyl 4'-(6-chloro-2-naphthamido)biphenyl-3-carboxylate | |
0.008 | - |
pH 8.8, 37°C | Homo sapiens | N-(3',4'-dimethoxybiphenyl-4-yl)-6-methoxynaphthalene-2-sulfonamide | |
0.008 | - |
pH 8.8, 37°C | Homo sapiens | N-(2,4'-dimethoxybiphenyl-4-yl)-6-methoxynaphthalene-2-sulfonamide | |
0.0081 | - |
pH 8.8, 37°C | Homo sapiens | N2-(3-chlorobiphenyl-4-yl)naphthalene-2,6-dicarboxamide | |
0.009 | - |
pH 8.8, 37°C | Homo sapiens | methyl 4'-(6-cyano-2-naphthamido)biphenyl-3-carboxylate | |
0.0098 | - |
pH 8.8, 37°C | Homo sapiens | N-(3'-methoxybiphenyl-4-yl)-2-naphthamide | |
0.0098 | - |
pH 8.8, 37°C | Homo sapiens | methyl 4'-(naphthalene-2-sulfonamido)biphenyl-4-carboxylate | |
0.011 | - |
pH 8.8, 37°C | Homo sapiens | methyl 4'-(6-bromo-2-naphthamido)biphenyl-3-carboxylate | |
0.012 | - |
pH 8.8, 37°C | Homo sapiens | 6-methoxy-N-(4'-methoxybiphenyl-4-yl)-2-naphthamide | |
0.013 | - |
pH 8.8, 37°C | Homo sapiens | 6-carbamimidoyl-N-phenyl-2-naphthamide | |
0.014 | - |
pH 8.8, 37°C | Homo sapiens | methyl 6-(3'-(methoxycarbonyl)biphenyl-4-ylcarbamoyl)-2-naphthoate | |
0.015 | - |
pH 8.8, 37°C | Homo sapiens | N2-phenylnaphthalene-2,6-dicarboxamide | |
0.016 | - |
pH 8.8, 37°C | Homo sapiens | methyl 4'-(2-naphthamido)biphenyl-3-carboxylate | |
0.016 | - |
pH 8.8, 37°C | Homo sapiens | methyl 4'-(naphthalene-2-sulfonamido)biphenyl-3-carboxylate | |
0.016 | - |
pH 8.8, 37°C | Homo sapiens | methyl 4'-(6-methoxynaphthalene-2-sulfonamido)biphenyl-4-carboxylate | |
0.019 | - |
pH 8.8, 37°C | Homo sapiens | 6-methoxy-N-(3'-methoxybiphenyl-4-yl)naphthalene-2-sulfonamide | |
0.02 | - |
pH 8.8, 37°C | Homo sapiens | 6-cyano-N-(3'-methoxybiphenyl-4-yl)-2-naphthamide | |
0.023 | - |
pH 8.8, 37°C | Homo sapiens | 6-methoxy-N-(4'-methoxybiphenyl-4-yl)naphthalene-2-sulfonamide | |
0.03 | - |
pH 8.8, 37°C | Homo sapiens | N2-(3,5-dimethoxyphenyl)naphthalene-2,6-dicarboxamide | |
0.031 | - |
pH 8.8, 37°C | Homo sapiens | N-(3',4'-dimethoxybiphenyl-4-yl)-6-methoxy-2-naphthamide | |
0.031 | - |
pH 8.8, 37°C | Homo sapiens | methyl 4'-(6-amino-2-naphthamido)biphenyl-3-carboxylate | |
0.031 | - |
pH 8.8, 37°C | Homo sapiens | N-(3'-methoxybiphenyl-4-yl)naphthalene-2-sulfonamide | |
0.031 | - |
pH 8.8, 37°C | Homo sapiens | N-(biphenyl-4-yl)-6-methoxynaphthalene-2-sulfonamide | |
0.045 | - |
pH 8.8, 37°C | Homo sapiens | N2-(4-(aminomethyl)phenyl)naphthalene-2,6-dicarboxamide trifluoroacetate | |
0.062 | - |
pH 8.8, 37°C | Homo sapiens | N-(3'-aminobiphenyl-4-yl)-6-methoxynaphthalene-2-sulfonamide |