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Literature summary for 3.4.21.73 extracted from

  • Krstic, J.; Obradovic, H.; Jaukovic, A.; Okic-Dordevic, I.; Trivanovic, D.; Kukolj, T.; Mojsilovic, S.; Ilic, V.; Santibanez, J.F.; Bugarski, D.
    Urokinase type plasminogen activator mediates interleukin-17-induced peripheral blood mesenchymal stem cell motility and transendothelial migration (2015), Biochim. Biophys. Acta, 1853, 431-444.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
plasminogen + H2O Homo sapiens
-
plasmin + ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P00749
-
-

Source Tissue

Source Tissue Comment Organism Textmining
mesenchymal stem cell
-
Homo sapiens
-
PC-3 cell
-
Homo sapiens
-
peripheral blood
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
casein + H2O
-
Homo sapiens ?
-
?
plasminogen + H2O
-
Homo sapiens plasmin + ?
-
?

Synonyms

Synonyms Comment Organism
uPA
-
Homo sapiens
urokinase type plasminogen activator
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens

Expression

Organism Comment Expression
Homo sapiens interleukin-17 induces enzyme production in peripheral blood mesenchymal stem cells, without affecting matrix metalloproteinase expression up

General Information

General Information Comment Organism
physiological function the enzyme mediates interleukin-17-induced peripheral blood mesenchymal stem cell motility and transendothelial migration without affecting matrix metalloproteinase expression, detailed overview. Interleukin-17 increases peripheral blood mesenchymal stem cell adhesion to endothelial cells and transendothelial migration, as well as increases the capacity of cell adhesion to fibronectin, in an urokinase-tyype plasminogen activator-dependent fashion Homo sapiens