Inhibitors | Comment | Organism | Structure |
---|---|---|---|
plasminogen activator inhibitor 1 | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
plasminogen + H2O | Homo sapiens | - |
plasmin + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | activation of human pro-urokinase by unrelated proteases secreted by Pseudomonas aeruginosa, e.g. LasB, a thermolysin-like metalloprotease, or protease IV, overview. Activation of pro-urokinase by purified LasB, or by the secretomes of Pseudomonas aeruginosa LasB-expressing or LasB-deficient strains | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | recombinant pro-uPA, expressed in Escherichia coli | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
benzoyl-beta-Ala-Gly-Arg-4-nitroanilide + H2O | - |
Homo sapiens | benzoyl-beta-Ala-Gly-Arg + 4-nitroaniline | - |
? | |
plasminogen + H2O | - |
Homo sapiens | plasmin + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
uPA-type Plg activator | - |
Homo sapiens |
Urokinase | - |
Homo sapiens |
urokinase-type Plg activator | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | LasB, a thermolysin-like metalloprotease secreted by Pseudomonas aeruginosa, converts the human uPA zymogen into its active form, processes the uPA receptor, inactivates the plasminogen activator inhibitor 1, and activates pro-matrix metalloproteinase 2 | Homo sapiens |