Literature summary for 3.4.21.73 extracted from

Iyer, A.M.; Zurolo, E.; Boer, K.; Baayen, J.C.; Giangaspero, F.; Arcella, A.; Di Gennaro, G.C.; Esposito, V.; Spliet, W.G.; van Rijen, P.C.; Troost, D.; Gorter, J.A.; Aronica, E.
Tissue plasminogen activator and urokinase plasminogen activator in human epileptogenic pathologies (2010), Neuroscience, 167, 929-945.

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Inhibitors

Inhibitors	Comment	Organism	Structure
plasminogen activator inhibitor type-1	i.e. PAI-1, an endogenous inhibitor protein	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Homo sapiens	-
brain cortex	-	Homo sapiens	-
ganglioma cell	-	Homo sapiens	-
glial cell	-	Homo sapiens	-
glioma cell	-	Homo sapiens	-
hippocampus	-	Homo sapiens	-
additional information	increased uPA expression in several epileptogenic pathologies, including hippocampal sclerosis, and in developmental glioneuronal lesions, such as focal cortical dysplasia, cortical tubers in patients with the tuberous sclerosis complex and in gangliogliomas, immunohistochemic analysis, overview	Homo sapiens	-
neuronal cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
uPA	-	Homo sapiens
Urokinase plasminogen activator	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	uPA overexpression in brain cortex and hippocampus is involved in epileptic pathology	Homo sapiens
physiological function	uPA elicits various cellular responses, involving the activation of distinct signaling pathways	Homo sapiens

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Release 2023.1 (January 2023)