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Literature summary for 3.4.21.73 extracted from
- Urokinase-type plasminogen activator induces BV-2 microglial cell migration through activation of matrix metalloproteinase-9 (2010), Neurochem. Res., 35, 976-985.
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 52000 | - |
x * 52000, SDS-PAGE | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| plasminogen + H2O | Mus musculus | - |
plasmin + ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| BV-2 cell | a murine microglial cell line | Mus musculus | - |
| microglia | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| plasminogen + H2O | - |
Mus musculus | plasmin + ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 52000, SDS-PAGE | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| uPA | - |
Mus musculus |
| Urokinase-type plasminogen activator | - |
Mus musculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.6 | - |
assay at | Mus musculus |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Mus musculus | uPA is induced by ATP in microglia. The expression and release of uPA is under active regulation in BV2 microglial cells | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| additional information | the expression and release of uPA is under active regulation in BV2 microglial cells | Mus musculus |
| physiological function | urokinase-type plasminogen activator induces BV-2 microglial cell migration through activation of matrix metalloproteinase-9 | Mus musculus |
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Release 2023.1 (January 2023)
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